Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 10236 NM_005826 POU5F1 protein expression hESC H1 M-010905-00 Z-score < -2 -0.217942635012275 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 16858 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 80.22 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 16858 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 106.1 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 16954 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 64.05 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 16954 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 95.01 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 17046 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 72.77 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 17046 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 57.21 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 135490 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 13.15 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10236 10236 Smoothed protein expression htRPE 135490 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 27.93 none GR00196-A-1 TP53 interactions (1) 21642980 10236 ENSG00000125944 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 10236 ENSG00000125944 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 -1.07 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 10236 10236 HCV replicon RNA copy number Huh7/Rep-Feo PL-50053 q-value Complex criteria 0.841 none GR00054-A Combinatorial effect with paclitaxel 17429401 10236 NM_005826 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.913 none GR00206-A Apoptosis regulation after Chlamydia trachomatis serovar L2 infection 21824245 10236 10236 Cleaved cytokeratin-18 protein expression HeLa np p-value <= 0.05 np none GR00213-A Circadian clock regulation 19765810 10236 NM_005826 Circadian clock Bmal1 reporter U2OS np Complex, sp Complex criteria np Decreased circadian period length double hit GR00056-A Melanogenesis 19057677 10236 NM_005826 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.845 none GR00098-A-1 Cell division (1) 17994010 10236 ENSG00000125944 Cell number and DNA content HeLa ENSG00000125944 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 10236 10236 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-010905-00 Z-score >= 2 0.34561879 none GR00053-A Genome stability 19647519 10236 NM_005826 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00232-A-1 DNA damage regulation after ionizing radiation (1) 20810650 10236 NM_005826 Ionizing radiation sensitivity U2OS v2HS_196591 log2 mean ratio < -1 OR > 1 -1.33971966633333 Increased ionizing radiation sensitivity GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 10236 10236 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-010905-00 Relative HR ratio < ~0.4 OR > 1.88 1.16908474561077 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 10236 NM_005826 Viability U251MG M-010905-00 Z-score > 4 3.82 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 10236 NM_005826 Viability (synthetic lethal) U251MG M-010905-00 Differential score > 3.6 AND viability Z-score < 4 -2.52 none Z-score 1.562 GR00242-A-1 Selective autophagy regulation (1) 22020285 10236 NM_005826 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 10236 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 9042 GR00249-S Vaccinia virus (VACV) infection 23401514 10236 10236 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-010905-09 Z-score >= 1 OR <= -1.5 -0.10754 none number of cells compared to control (%): 101.60 GR00249-S Vaccinia virus (VACV) infection 23401514 10236 10236 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-010905-02 Z-score >= 1 OR <= -1.5 -0.22376 none number of cells compared to control (%): 84.66 GR00249-S Vaccinia virus (VACV) infection 23401514 10236 10236 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s19979 Z-score >= 1 OR <= -1.5 0.35753 none number of cells compared to control (%): 86.00 GR00249-S Vaccinia virus (VACV) infection 23401514 10236 10236 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s19980 Z-score >= 1 OR <= -1.5 -1.12178 none number of cells compared to control (%): 73.75 GR00249-S Vaccinia virus (VACV) infection 23401514 10236 10236 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s19981 Z-score >= 1 OR <= -1.5 0.0213 none number of cells compared to control (%): 91.84 GR00253-A hepcidin regulation 24385536 10236 NM_005826 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 -0.654 none GR00254-A SMN2 splicing regulation 22325991 10236 SMN2-based splicing reporter expression HeLa np SMN2 FL/deltaexon 7 ratio np np none GR00255-A-1 Negative genetic interactions (1) 24104479 10236 10236 shRNA abundance HCT116 TRCN0000001238,TRCN0000001239,TRCN0000001240,TRCN0000001241,TRCN0000001242 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.673627691 none GR00255-A-2 Negative genetic interactions (2) 24104479 10236 10236 shRNA abundance HCT116 TRCN0000001238,TRCN0000001239,TRCN0000001240,TRCN0000001241,TRCN0000001242 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.199408317 none GR00255-A-3 Negative genetic interactions (3) 24104479 10236 10236 shRNA abundance HCT116 TRCN0000001238,TRCN0000001239,TRCN0000001240,TRCN0000001241,TRCN0000001242 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.418808453 none GR00255-A-4 Negative genetic interactions (4) 24104479 10236 10236 shRNA abundance HCT116 TRCN0000001238,TRCN0000001239,TRCN0000001240,TRCN0000001241,TRCN0000001242 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.280571503 none GR00255-A-5 Negative genetic interactions (5) 24104479 10236 10236 shRNA abundance HCT116 TRCN0000001238,TRCN0000001239,TRCN0000001240,TRCN0000001241,TRCN0000001242 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.297164252 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 10236 NM_005826 Wnt pathway reporter HeLa M-010905-00 Z-score > 4 -0.91 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 10236 NM_005826 Wnt pathway reporter HeLa M-010905-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 10236 Viability HCC366 np Z-score < -2.5 -0.345 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 10236 shRNA abundance A375 TRCN0000001240,TRCN0000001241,TRCN0000001238,TRCN0000001239,TRCN0000001242 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 10236 NM_005826 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -0.34 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 10236 10236 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -1.34 none GR00312-A NOD2 pathway regulation 23322906 10236 10236 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 38.7 none 87,5% viability GR00313-A TNF-alpha pathway regulation 22733992 10236 NM_005826 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -0.11 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10236 10236 shRNA abundance K562 TRCN0000001240 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.2900000000000009 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10236 10236 shRNA abundance K562 TRCN0000001239 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.7425000000000015 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10236 10236 shRNA abundance K562 TRCN0000001241 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.26750000000000007 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10236 10236 shRNA abundance K562 TRCN0000001242 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.6500000000000004 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10236 10236 shRNA abundance K562 TRCN0000001238 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.4749999999999961 none GR00369-A Combinatorial effect with FBW7 26354767 10236 10236 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean 0.06 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 10236 10236 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.445616780438 none Ambion GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 10236 10236 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.184213882041 none Ambion GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 10236 10236 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.0483422542614 none Ambion GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 10236 10236 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.0535302512201 none Ambion GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 10236 10236 Viability KB cells [object Object] RSA P-value <0.001 0.011174701 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 10236 10236 Viability KB cells [object Object] RSA P-value <0.001 0.483217356 none GR00378-A Poliovirus vaccine production 26581994 10236 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -0.735949047 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 10236 NM_005826 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 43.357 none GR00386-A-1 NOD2 stimulation by MDP 25170077 10236 10236 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 88.8828494275315 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 10236 10236 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 16.5 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 10236 10236 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-010905-02 Z-score >=5.13 -0.08 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 10236 10236 The percentage of infected cells A549 SIR0009303 Z-score > 5 -0.6363540484160876 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 10236 10236 The percentage of infected cells A549 SIR0009303 Z-score > -3 -0.5393474900995079 no effect 5 days post-infection