Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 10745 NM_006608 POU5F1 protein expression hESC H1 M-020049-00 Z-score < -2 -1.34443697839193 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3391 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -17.47 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3391 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -21.53 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3487 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -53.74 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3487 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -88.36 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3579 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -72.87 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 3579 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -49.65 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 108062 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 5.96 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 10745 10745 Smoothed protein expression htRPE 108062 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -45.59 none GR00196-A-1 TP53 interactions (1) 21642980 10745 ENSG00000116793 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00018-A-0 Synthetic lethal interaction with Ras 19490893 10745 Synthetic lethal interaction with Ras DLD-1 v2HS_209334 Log2 diff MUT-WT (and P-value) -0.7 (0.3) -1.19 (0.12) Synthetic lethal with Ras GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 10745 ENSG00000116793 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.659 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 10745 10745 HCV replicon RNA copy number Huh7/Rep-Feo PL-50009 q-value Complex criteria 0.841 none GR00054-A Combinatorial effect with paclitaxel 17429401 10745 NM_006608 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.974 none GR00056-A Melanogenesis 19057677 10745 NM_006608 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 1.046 none GR00098-A-1 Cell division (1) 17994010 10745 ENSG00000116793 Cell number and DNA content HeLa ENSG00000116793 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 10745 10745 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-020049-00 Z-score >= 2 1.479935494 none GR00053-A Genome stability 19647519 10745 NM_006608 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 10745 10745 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-020049-00 Relative HR ratio < ~0.4 OR > 1.88 1.61050977094556 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 10745 NM_006608 Viability U251MG M-020049-00 Z-score > 4 -0.9 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 10745 NM_006608 Viability (synthetic lethal) U251MG M-020049-00 Differential score > 3.6 AND viability Z-score < 4 1.04 none Z-score 0.1695 GR00242-A-1 Selective autophagy regulation (1) 22020285 10745 NM_006608 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 10745 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 17841 GR00249-S Vaccinia virus (VACV) infection 23401514 10745 10745 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-020049-05 Z-score >= 1 OR <= -1.5 0.35834 none number of cells compared to control (%): 76.50 GR00249-S Vaccinia virus (VACV) infection 23401514 10745 10745 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-020049-01 Z-score >= 1 OR <= -1.5 -0.44057 none number of cells compared to control (%): 75.42 GR00249-S Vaccinia virus (VACV) infection 23401514 10745 10745 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s21113 Z-score >= 1 OR <= -1.5 1.89573 Increased vaccinia virus (VACV) infection number of cells compared to control (%): 89.40 GR00249-S Vaccinia virus (VACV) infection 23401514 10745 10745 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s21114 Z-score >= 1 OR <= -1.5 0.58692 none number of cells compared to control (%): 115.07 GR00249-S Vaccinia virus (VACV) infection 23401514 10745 10745 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s21115 Z-score >= 1 OR <= -1.5 -2.21086 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 65.97 GR00253-A hepcidin regulation 24385536 10745 NM_006608 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 -1.372 none GR00255-A-1 Negative genetic interactions (1) 24104479 10745 10745 shRNA abundance HCT116 TRCN0000014693,TRCN0000014694,TRCN0000014695,TRCN0000014696,TRCN0000014697 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.040999967 none GR00255-A-2 Negative genetic interactions (2) 24104479 10745 10745 shRNA abundance HCT116 TRCN0000014693,TRCN0000014694,TRCN0000014695,TRCN0000014696,TRCN0000014697 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.184342204 none GR00255-A-3 Negative genetic interactions (3) 24104479 10745 10745 shRNA abundance HCT116 TRCN0000014693,TRCN0000014694,TRCN0000014695,TRCN0000014696,TRCN0000014697 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.4112186 none GR00255-A-4 Negative genetic interactions (4) 24104479 10745 10745 shRNA abundance HCT116 TRCN0000014693,TRCN0000014694,TRCN0000014695,TRCN0000014696,TRCN0000014697 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.150195576 none GR00255-A-5 Negative genetic interactions (5) 24104479 10745 10745 shRNA abundance HCT116 TRCN0000014693,TRCN0000014694,TRCN0000014695,TRCN0000014696,TRCN0000014697 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.433949328 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 10745 NM_006608 Wnt pathway reporter HeLa M-020049-00 Z-score > 4 3.33 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 10745 NM_006608 Wnt pathway reporter HeLa M-020049-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 10745 Viability HCC366 np Z-score < -2.5 -0.776 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 10745 shRNA abundance A375 TRCN0000014694,TRCN0000014693,TRCN0000014696,TRCN0000014695,TRCN0000014697 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 10745 NM_006608 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -0.25 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 10745 10745 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 0.46 none GR00312-A NOD2 pathway regulation 23322906 10745 10745 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability -1.8 none 92,2% viability GR00313-A TNF-alpha pathway regulation 22733992 10745 NM_006608 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters 0.18 none GR00318-A Huntingtin toxicity 23209424 10745 10745 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 1.383 none siRNA set: druggable genome GR00095-A p53 pathway components 15042092 10745 NM_006608 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10745 10745 shRNA abundance K562 TRCN0000014695 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.5225000000000009 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10745 10745 shRNA abundance K562 TRCN0000014694 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.5399999999999991 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10745 10745 shRNA abundance K562 TRCN0000014696 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.7049999999999992 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10745 10745 shRNA abundance K562 TRCN0000014693 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.3699999999999992 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 10745 10745 shRNA abundance K562 TRCN0000014697 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.9775000000000009 none GR00123-A Combinatorial effect with nutlin-3 16474381 10745 NM_006608 Viability MCF-7 176781,176782,176783 log2 ratio np np none GR00360-A-1 Secretory transport (1) 22660414 10745 ENSG00000116793 CFP-tsO45G cell surface transport HeLa Kyoto 108062 Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) 0.8688600000000001 Mildly decreased CFP-tsO45G cell surface transport GR00360-A-1 Secretory transport (1) 22660414 10745 ENSG00000116793 CFP-tsO45G cell surface transport HeLa Kyoto 108063 Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) 1.1981 Strongly decreased CFP-tsO45G cell surface transport GR00360-A-2 Secretory transport (2) 22660414 10745 ENSG00000116793 CFP-tsO45G cell surface transport HeLa Kyoto SI00684173 Deviation score > 1.0 2.78 Strongly decreased CFP-tsO45G cell surface transport GR00369-A Combinatorial effect with FBW7 26354767 10745 10745 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.04 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 10745 10745 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.817741356462 none Ambion GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 10745 PHTF1 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -1.16547913074 none Ambion GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 10745 10745 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -1.19146395433 none Ambion GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 10745 10745 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -1.08946597902 none Ambion GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 10745 10745 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -1.35133856315 none Ambion GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 10745 10745 Viability KB cells [object Object] RSA P-value <0.001 0.171389925 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 10745 10745 Viability KB cells [object Object] RSA P-value <0.001 0.511223546 none GR00378-A Poliovirus vaccine production 26581994 10745 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -1.632693776 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 10745 NM_006608 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 50.622 none GR00386-A-1 NOD2 stimulation by MDP 25170077 10745 10745 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 81.3575111020366 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 10745 10745 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -51.4 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 10745 10745 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-020049-01 Z-score >=5.13 -0.54 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 10745 10745 The percentage of infected cells A549 SIR0001544 Z-score > 5 -3.5184387428871586 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 10745 10745 The percentage of infected cells A549 SIR0001544 Z-score > -3 0.2663221578202962 no effect 5 days post-infection