Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 1244 NM_000392 POU5F1 protein expression hESC H1 M-004225-00 Z-score < -2 -0.292020059720926 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 2527 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 71.7 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 2527 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean np none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 116839 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 0.27 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 116839 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -20.33 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 116840 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 19.08 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 1244 1244 Smoothed protein expression htRPE 116840 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 25.25 none GR00196-A-1 TP53 interactions (1) 21642980 1244 ENSG00000023839 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00133-A-1 Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) 21407211 1244 1244 Gentamycin protection invasion assay HeLa np log2 median Complex criteria -0.347694 none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 1244 ENSG00000023839 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.796 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 1244 1244 HCV replicon RNA copy number Huh7/Rep-Feo PL-50019 q-value Complex criteria 0.922 none GR00054-A Combinatorial effect with paclitaxel 17429401 1244 NM_000392 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.773 none GR00056-A Melanogenesis 19057677 1244 NM_000392 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 1.051 none GR00098-A-1 Cell division (1) 17994010 1244 ENSG00000023839 Cell number and DNA content HeLa ENSG00000023839 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 1244 1244 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-004225-00 Z-score >= 2 1.306145924 none GR00016-A Wnt/beta-catenin pathway regulation 19471023 1244 1244 Wnt/beta-catenin pathway reporter RKO np Z-score > 2 1.06 none GR00053-A Genome stability 19647519 1244 NM_000392 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 1244 1244 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-004225-00 Relative HR ratio < ~0.4 OR > 1.88 1.17091688060573 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 1244 NM_000392 Viability U251MG M-004225-00 Z-score > 4 0.15 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 1244 NM_000392 Viability (synthetic lethal) U251MG M-004225-00 Differential score > 3.6 AND viability Z-score < 4 2.18 none Z-score 2.5415 GR00242-A-1 Selective autophagy regulation (1) 22020285 1244 NM_000392 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 1244 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 9191 GR00249-S Vaccinia virus (VACV) infection 23401514 1244 1244 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-004225-05 Z-score >= 1 OR <= -1.5 -0.9646 none number of cells compared to control (%): 76.28 GR00249-S Vaccinia virus (VACV) infection 23401514 1244 1244 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-004225-01 Z-score >= 1 OR <= -1.5 1.3715 Increased vaccinia virus (VACV) infection number of cells compared to control (%): 69.93 GR00249-S Vaccinia virus (VACV) infection 23401514 1244 1244 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s3227 Z-score >= 1 OR <= -1.5 -0.82701 none number of cells compared to control (%): 81.01 GR00249-S Vaccinia virus (VACV) infection 23401514 1244 1244 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s3228 Z-score >= 1 OR <= -1.5 0.18128 none number of cells compared to control (%): 88.87 GR00249-S Vaccinia virus (VACV) infection 23401514 1244 1244 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s3229 Z-score >= 1 OR <= -1.5 1.11071 Increased vaccinia virus (VACV) infection number of cells compared to control (%): 82.32 GR00253-A hepcidin regulation 24385536 1244 NM_000392 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 1.67 none GR00255-A-1 Negative genetic interactions (1) 24104479 1244 1244 shRNA abundance HCT116 TRCN0000059303,TRCN0000059304,TRCN0000059305,TRCN0000059306,TRCN0000059307 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.556524925 none GR00255-A-2 Negative genetic interactions (2) 24104479 1244 1244 shRNA abundance HCT116 TRCN0000059303,TRCN0000059304,TRCN0000059305,TRCN0000059306,TRCN0000059307 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.313218932 none GR00255-A-3 Negative genetic interactions (3) 24104479 1244 1244 shRNA abundance HCT116 TRCN0000059303,TRCN0000059304,TRCN0000059305,TRCN0000059306,TRCN0000059307 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.280800779 none GR00255-A-4 Negative genetic interactions (4) 24104479 1244 1244 shRNA abundance HCT116 TRCN0000059303,TRCN0000059304,TRCN0000059305,TRCN0000059306,TRCN0000059307 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.109125857 none GR00255-A-5 Negative genetic interactions (5) 24104479 1244 1244 shRNA abundance HCT116 TRCN0000059303,TRCN0000059304,TRCN0000059305,TRCN0000059306,TRCN0000059307 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.078419667 none GR00257-A-1 Cell division, migration and survival (1) 20360735 1244 H2B-GFP protein expression HeLa 116839 Complex, sp Complex criteria sp Dynamic nuclei (hole, folded or small irregular) GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 1244 NM_000392 Wnt pathway reporter HeLa M-004225-00 Z-score > 4 0.13 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 1244 NM_000392 Wnt pathway reporter HeLa M-004225-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 1244 Viability HCC366 np Z-score < -2.5 -0.221 none GR00297-A Glucose limitation response 24670634 1244 shRNA abundance in high and low glucose Jurkat TRCN0000059303 Log2 ratio < -0.75 -0.34 none GR00297-A Glucose limitation response 24670634 1244 shRNA abundance in high and low glucose Jurkat TRCN0000059305 Log2 ratio < -0.75 -0.48 none GR00297-A Glucose limitation response 24670634 1244 shRNA abundance in high and low glucose Jurkat TRCN0000059307 Log2 ratio < -0.75 0.15 none GR00297-A Glucose limitation response 24670634 1244 shRNA abundance in high and low glucose Jurkat TRCN0000059306 Log2 ratio < -0.75 0.05 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 1244 shRNA abundance A375 TRCN0000059305,TRCN0000059304,TRCN0000059307,TRCN0000059306,TRCN0000059303 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 1244 NM_000392 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 1.38 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 1244 1244 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -0.18 none GR00312-A NOD2 pathway regulation 23322906 1244 1244 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability -20 none 100,6% viability GR00313-A TNF-alpha pathway regulation 22733992 1244 NM_000392 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -0.52 none GR00318-A Huntingtin toxicity 23209424 1244 1244 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 1.783 none siRNA set: druggable genome GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012453 Z-score > 2.24 -0.441934215041097 none GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012452 Z-score > 2.24 -0.2113646622136155 none GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012448 Z-score > 2.24 -2.0001840893801615 none GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012449 Z-score > 2.24 -0.5663419891167142 none GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012450 Z-score > 2.24 -0.2122816507350954 none GR00327-A Tumor formation 24292671 1244 1244 shRNA abundance SUM-149 CLL-H-012451 Z-score > 2.24 0.8929965806007448 none GR00095-A p53 pathway components 15042092 1244 NM_000392 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00123-A Combinatorial effect with nutlin-3 16474381 1244 NM_000392 Viability MCF-7 144382,144383,144381 log2 ratio np np none GR00350-A Human papilloma virus (HPV) infection 24874089 1244 1244 HPV16-GFP infection HeLa np Average z-score of 3 siRNAs < -3 OR > 3 np Decreased HPV16-GFP infection confirmed in secondary screen GR00360-A-1 Secretory transport (1) 22660414 1244 ENSG00000023839 CFP-tsO45G cell surface transport HeLa Kyoto 116839 Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) 0.9519000000000001 Mildly decreased CFP-tsO45G cell surface transport GR00363-A Endocytosis regulation 20190736 1244 1244 Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content HeLa SI00008603,118135,SI00008610,SI00008624,116839,esi439,116840,SI00008617 Complex, sp Complex criteria sp Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region) strong GR00369-A Combinatorial effect with FBW7 26354767 1244 1244 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.06000000000000001 none GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 1244 1244 Viability KB cells [object Object] RSA P-value <0.001 0.527537342 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 1244 1244 Viability KB cells [object Object] RSA P-value <0.001 0.122660209 none GR00378-A Poliovirus vaccine production 26581994 1244 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -0.258989257 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 1244 NM_000392 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 20.392 Decreased viability GR00381-A-2 Regulation of mammary epithelial cell growth (2) 25572802 1244 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 22.518982283202345 Decreased viability Plasma Membrane; transporter GR00381-A-3 Regulation of mammary epithelial cell growth (3) 25572802 1244 Viability 184-hTERT-E11 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 20.26888341543514 Decreased viability Plasma Membrane; transporter GR00386-A-1 NOD2 stimulation by MDP 25170077 1244 1244 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 103.051145934357 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 1244 1244 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -159.2 none GR00396-S Mammosphere formation and maintenance 24229464 1244 NM_000392.1 shRNA quantification SUM149 p-value <0.01 0.08147963212898261 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 1244 1244 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-004225-01 Z-score >=5.13 -0.36 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 1244 1244 The percentage of infected cells A549 SIR0004895 Z-score > 5 -1.1994435873153433 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 1244 1244 The percentage of infected cells A549 SIR0004895 Z-score > -3 -1.5621387812414742 no effect 5 days post-infection