Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 XM_379797 POU5F1 protein expression hESC H1 M-028996-00 Z-score < -2 -1.03376144430473 none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 NM_207434 POU5F1 protein expression hESC H1 M-032110-00 Z-score < -2 -1.14638313220766 none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 XM_376048 POU5F1 protein expression hESC H1 M-027828-00 Z-score < -2 -1.31192556358257 none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 XM_371736 POU5F1 protein expression hESC H1 M-028516-00 Z-score < -2 -1.34498702377541 none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 XM_209180 POU5F1 protein expression hESC H1 M-026191-00 Z-score < -2 -1.51844137219048 none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 129880 NM_152384 POU5F1 protein expression hESC H1 M-016478-00 Z-score < -2 -1.68220795343151 none GR00196-A-1 TP53 interactions (1) 21642980 129880 ENSG00000163093 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 129880 ENSG00000163093 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 1.081 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 129880 129880 HCV replicon RNA copy number Huh7/Rep-Feo PL-50072 q-value Complex criteria 0.856 none GR00054-A Combinatorial effect with paclitaxel 17429401 129880 NM_152384 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.967 none GR00056-A Melanogenesis 19057677 129880 NM_152384 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.966 none GR00098-A-1 Cell division (1) 17994010 129880 ENSG00000163093 Cell number and DNA content HeLa ENSG00000163093 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 129880 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-016478-00 Z-score >= 2 -0.733735271 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 284397 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-026191-00 Z-score >= 2 0.78633123 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 400949 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-027828-00 Z-score >= 2 0.36398781 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 389286 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-028516-00 Z-score >= 2 1.584020449 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 402469 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-028996-00 Z-score >= 2 -1.056393631 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 129880 400002 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-032110-00 Z-score >= 2 0.05394674 none GR00053-A Genome stability 19647519 129880 NM_152384 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp Increased gamma-H2AX phosphorylation group 2 GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 389286 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-028516-00 Relative HR ratio < ~0.4 OR > 1.88 1.12629527990129 none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 129880 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-016478-00 Relative HR ratio < ~0.4 OR > 1.88 1.17016793896914 none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 284397 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-026191-00 Relative HR ratio < ~0.4 OR > 1.88 1.26207869047304 none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 400949 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-027828-00 Relative HR ratio < ~0.4 OR > 1.88 1.29736760936519 none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 402469 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-028996-00 Relative HR ratio < ~0.4 OR > 1.88 1.2978807452621 none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 129880 400002 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-032110-00 Relative HR ratio < ~0.4 OR > 1.88 1.08677801057316 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 XM_379797 Viability U251MG M-028996-00 Z-score > 4 -0.82 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 XM_371736 Viability U251MG M-028516-00 Z-score > 4 1.89 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 XM_376048 Viability U251MG M-027828-00 Z-score > 4 1.01 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 XM_209180 Viability U251MG M-026191-00 Z-score > 4 0.82 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 NM_152384 Viability U251MG M-016478-00 Z-score > 4 0.56 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 129880 NM_207434 Viability U251MG M-032110-00 Z-score > 4 0.23 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 XM_379797 Viability (synthetic lethal) U251MG M-028996-00 Differential score > 3.6 AND viability Z-score < 4 1.89 none Z-score 1.2995 GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 XM_376048 Viability (synthetic lethal) U251MG M-027828-00 Differential score > 3.6 AND viability Z-score < 4 1.4 none Z-score 2.6135 GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 XM_209180 Viability (synthetic lethal) U251MG M-026191-00 Differential score > 3.6 AND viability Z-score < 4 1.25 none Z-score 2.316 GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 XM_371736 Viability (synthetic lethal) U251MG M-028516-00 Differential score > 3.6 AND viability Z-score < 4 0.76 none Z-score 2.765 GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 NM_207434 Viability (synthetic lethal) U251MG M-032110-00 Differential score > 3.6 AND viability Z-score < 4 2.42 none Z-score 2.7715 GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 129880 NM_152384 Viability (synthetic lethal) U251MG M-016478-00 Differential score > 3.6 AND viability Z-score < 4 0.43 none Z-score 1.206 GR00242-A-1 Selective autophagy regulation (1) 22020285 129880 NM_152384 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 129880 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 3050 GR00249-S Vaccinia virus (VACV) infection 23401514 129880 129880 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-016478-09 Z-score >= 1 OR <= -1.5 0.3183 none number of cells compared to control (%): 85.70 GR00249-S Vaccinia virus (VACV) infection 23401514 129880 129880 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-016478-01 Z-score >= 1 OR <= -1.5 -0.70434 none number of cells compared to control (%): 56.66 GR00249-S Vaccinia virus (VACV) infection 23401514 129880 129880 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s43452 Z-score >= 1 OR <= -1.5 0.5699 none number of cells compared to control (%): 91.33 GR00249-S Vaccinia virus (VACV) infection 23401514 129880 129880 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s43453 Z-score >= 1 OR <= -1.5 -0.55433 none number of cells compared to control (%): 83.05 GR00249-S Vaccinia virus (VACV) infection 23401514 129880 129880 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s43454 Z-score >= 1 OR <= -1.5 0.97564 none number of cells compared to control (%): 103.18 GR00253-A hepcidin regulation 24385536 129880 NM_152384 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 1.04 none GR00255-A-1 Negative genetic interactions (1) 24104479 129880 129880 shRNA abundance HCT116 TRCN0000118757,TRCN0000118758,TRCN0000118759,TRCN0000118760,TRCN0000118761 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.104695716 none GR00255-A-2 Negative genetic interactions (2) 24104479 129880 129880 shRNA abundance HCT116 TRCN0000118757,TRCN0000118758,TRCN0000118759,TRCN0000118760,TRCN0000118761 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.383981915 none GR00255-A-3 Negative genetic interactions (3) 24104479 129880 129880 shRNA abundance HCT116 TRCN0000118757,TRCN0000118758,TRCN0000118759,TRCN0000118760,TRCN0000118761 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.564530245 none GR00255-A-4 Negative genetic interactions (4) 24104479 129880 129880 shRNA abundance HCT116 TRCN0000118757,TRCN0000118758,TRCN0000118759,TRCN0000118760,TRCN0000118761 differential Gene Activity Ranking Profile (dGARP) < -1.2 -1.217560087 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-5 Negative genetic interactions (5) 24104479 129880 129880 shRNA abundance HCT116 TRCN0000118757,TRCN0000118758,TRCN0000118759,TRCN0000118760,TRCN0000118761 differential Gene Activity Ranking Profile (dGARP) < -0.8 0.648579364 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 XM_371736 Wnt pathway reporter HeLa M-028516-00 Z-score > 4 -0.42 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 XM_379797 Wnt pathway reporter HeLa M-028996-00 Z-score > 4 -0.51 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 XM_209180 Wnt pathway reporter HeLa M-026191-00 Z-score > 4 -0.56 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 NM_152384 Wnt pathway reporter HeLa M-016478-00 Z-score > 4 -1.1 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 XM_376048 Wnt pathway reporter HeLa M-027828-00 Z-score > 4 0.16 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 129880 NM_207434 Wnt pathway reporter HeLa M-032110-00 Z-score > 4 -0.08 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 NM_152384 Wnt pathway reporter HeLa M-016478-00 Complex, SP Complex criteria sp none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 NM_207434 Wnt pathway reporter HeLa M-032110-00 Complex, SP Complex criteria sp none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 XM_209180 Wnt pathway reporter HeLa M-026191-00 Complex, SP Complex criteria sp none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 XM_376048 Wnt pathway reporter HeLa M-027828-00 Complex, SP Complex criteria sp none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 XM_371736 Wnt pathway reporter HeLa M-028516-00 Complex, SP Complex criteria sp none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 129880 XM_379797 Wnt pathway reporter HeLa M-028996-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 129880 Viability HCC366 np Z-score < -2.5 -4.923 Decreased viability with paclitaxel final hit GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 129880 shRNA abundance A375 TRCN0000118759,TRCN0000118757,TRCN0000118758,TRCN0000118760,TRCN0000118761 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 129880 NM_152384 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 0 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 129880 129880 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -1.04 none GR00312-A NOD2 pathway regulation 23322906 129880 129880 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 57.3 none 68,6% viability GR00313-A TNF-alpha pathway regulation 22733992 129880 NM_152384 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -0.21 none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011237 Z-score > 2.24 np none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011232 Z-score > 2.24 0.5114464432986109 none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011235 Z-score > 2.24 1.1190177180529894 none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011236 Z-score > 2.24 -0.7573499620357358 none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011233 Z-score > 2.24 0.7810716078963214 none GR00327-A Tumor formation 24292671 129880 428 shRNA abundance SUM-149 CLL-H-011234 Z-score > 2.24 -1.267617870062375 none GR00369-A Combinatorial effect with FBW7 26354767 129880 129880 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.05000000000000002 none GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 129880 129880 Viability KB cells [object Object] RSA P-value <0.001 0.894771632 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 129880 129880 Viability KB cells [object Object] RSA P-value <0.001 0.213617119 none GR00378-A Poliovirus vaccine production 26581994 129880 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -0.557987178 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 129880 NM_152384 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 63.755 none GR00386-A-1 NOD2 stimulation by MDP 25170077 129880 129880 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 73.998810574053 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 129880 129880 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 9.3 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 129880 129880 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-016478-01 Z-score >=5.13 0.18 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 129880 129880 The percentage of infected cells A549 SIR0015297 Z-score > 5 -2.0815227399099956 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 129880 129880 The percentage of infected cells A549 SIR0015297 Z-score > -3 1.2760883521421316 no effect 5 days post-infection