Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 1945 NM_005227 POU5F1 protein expression hESC H1 M-006858-01 Z-score < -2 -0.71695965493116 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 1945 1945 HCV replicon RNA copy number Huh7/Rep-Feo PL-50010 q-value Complex criteria 0.918 none GR00054-A Combinatorial effect with paclitaxel 17429401 1945 NM_005227 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.826 none GR00056-A Melanogenesis 19057677 1945 NM_005227 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.969 none GR00098-A-1 Cell division (1) 17994010 1945 ENSG00000143620 Cell number and DNA content HeLa ENSG00000143620 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 1945 1945 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-006858-01 Z-score >= 2 -0.584048652 none GR00053-A Genome stability 19647519 1945 NM_005227 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00235-A Proliferation and survival of human cancer cell lines 21746896 1945 Viability 786-O, A-204, A549, A2058, A2780, AGS, AsPC-1, BxPC-3, C2BBe1, Caov-3, Caov-4, CFPAC-1, CH-157MN, COLO 205, COLO-704, COLO 741, COV362, COV434, COV504, DLD-1, EFO-21, EFO-27, F5, GP2d, HCC70, HCC364, HCC827, HCC2814, HEC-1-A, Hey-A8, HL-60, HLF, HPAC, Hs np Rank Complex criteria np Decreased viability in non-small-cell lung cancer (NSCLC) lineage NSCLC: no filter, two analyses GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 1945 1945 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-006858-01 Relative HR ratio < ~0.4 OR > 1.88 1.26871275461051 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 1945 NM_005227 Viability U251MG M-006858-01 Z-score > 4 1.84 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 1945 NM_005227 Viability (synthetic lethal) U251MG M-006858-01 Differential score > 3.6 AND viability Z-score < 4 -1.82 none Z-score 0.026 GR00242-A-1 Selective autophagy regulation (1) 22020285 1945 NM_005227 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 1945 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 18301 GR00249-S Vaccinia virus (VACV) infection 23401514 1945 1945 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-006858-06 Z-score >= 1 OR <= -1.5 -1.01133 none number of cells compared to control (%): 67.55 GR00249-S Vaccinia virus (VACV) infection 23401514 1945 1945 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-006858-01 Z-score >= 1 OR <= -1.5 0.27383 Decreased viability number of cells compared to control (%): 42.63 GR00249-S Vaccinia virus (VACV) infection 23401514 1945 1945 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s4504 Z-score >= 1 OR <= -1.5 1.27145 Increased vaccinia virus (VACV) infection number of cells compared to control (%): 97.71 GR00249-S Vaccinia virus (VACV) infection 23401514 1945 1945 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s4505 Z-score >= 1 OR <= -1.5 0.33369 none number of cells compared to control (%): 98.72 GR00249-S Vaccinia virus (VACV) infection 23401514 1945 1945 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s4506 Z-score >= 1 OR <= -1.5 -2.46963 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 101.63 GR00253-A hepcidin regulation 24385536 1945 NM_005227 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 -0.557 none GR00255-A-1 Negative genetic interactions (1) 24104479 1945 1945 shRNA abundance HCT116 TRCN0000059198,TRCN0000059199,TRCN0000059200,TRCN0000059201,TRCN0000059202 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.296218112 none GR00255-A-2 Negative genetic interactions (2) 24104479 1945 1945 shRNA abundance HCT116 TRCN0000059198,TRCN0000059199,TRCN0000059200,TRCN0000059201,TRCN0000059202 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.117806979 none GR00255-A-3 Negative genetic interactions (3) 24104479 1945 1945 shRNA abundance HCT116 TRCN0000059198,TRCN0000059199,TRCN0000059200,TRCN0000059201,TRCN0000059202 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.441171643 none GR00255-A-4 Negative genetic interactions (4) 24104479 1945 1945 shRNA abundance HCT116 TRCN0000059198,TRCN0000059199,TRCN0000059200,TRCN0000059201,TRCN0000059202 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.068077278 none GR00255-A-5 Negative genetic interactions (5) 24104479 1945 1945 shRNA abundance HCT116 TRCN0000059198,TRCN0000059199,TRCN0000059200,TRCN0000059201,TRCN0000059202 differential Gene Activity Ranking Profile (dGARP) < -0.8 0.016456171 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 1945 NM_005227 Wnt pathway reporter HeLa M-006858-01 Z-score > 4 -0.79 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 1945 NM_005227 Wnt pathway reporter HeLa M-006858-01 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 1945 Viability HCC366 np Z-score < -2.5 0.628 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 1945 shRNA abundance A375 TRCN0000059200,TRCN0000059202,TRCN0000059198,TRCN0000059201,TRCN0000059199 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 1945 NM_005227 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -2.05 none GR00306-A Human papillomavirus 16 (HPV16) infection 23569269 1945 1945 HPV16 pseudovirus reporter HeLa-S3 np Modified activity score (MAS1) Top 1000 39.81 Decreased human papilloma virus 16 (HPV16) pseudovirus infection GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 1945 1945 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 0.42 none GR00312-A NOD2 pathway regulation 23322906 1945 1945 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 2 none 108,6% viability GR00313-A TNF-alpha pathway regulation 22733992 1945 NM_005227 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -1.14 none GR00318-A Huntingtin toxicity 23209424 1945 1945 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 0.779 none siRNA set: druggable genome GR00327-A Tumor formation 24292671 1945 2164 shRNA abundance SUM-149 CLL-H-008838 Z-score > 2.24 -1.0722247800019775 none GR00327-A Tumor formation 24292671 1945 2164 shRNA abundance SUM-149 CLL-H-008836 Z-score > 2.24 -1.4664239829060153 none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000109 Z-score > 2.24 0.37261941098019985 none GR00327-A Tumor formation 24292671 1945 2164 shRNA abundance SUM-149 CLL-H-008834 Z-score > 2.24 0.4622200212507638 none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000111 Z-score > 2.24 0.31816083662788397 none GR00327-A Tumor formation 24292671 1945 2164 shRNA abundance SUM-149 CLL-H-008837 Z-score > 2.24 0.40082919866699307 none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000112 Z-score > 2.24 -0.42961063892005197 none GR00327-A Tumor formation 24292671 1945 2164 shRNA abundance SUM-149 CLL-H-008835 Z-score > 2.24 np none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000113 Z-score > 2.24 -0.7375669035321436 none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000108 Z-score > 2.24 -1.2638408481163046 none GR00327-A Tumor formation 24292671 1945 1945 shRNA abundance SUM-149 CLL-H-000110 Z-score > 2.24 -1.758100365642723 none GR00095-A p53 pathway components 15042092 1945 NM_005227 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00123-A Combinatorial effect with nutlin-3 16474381 1945 NM_005227 Viability MCF-7 138483,138482,174412,174411,174413,138481 log2 ratio np np none GR00362-A Vaccinia virus (VACV) replication 2401222 1945 1945 VACV-A5eGFP expression HeLa np Z-score <= -2 OR >= 2 np Synthetic lethal with vaccinia virus (VACV) infection GR00369-A Combinatorial effect with FBW7 26354767 1945 1945 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.03 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 1945 1945 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.0532321864946 none Dharmacon GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 1945 EFNA4 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.0433360441224 none Dharmacon GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 1945 1945 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.363121116924 none Dharmacon GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 1945 1945 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.638660059475 none Dharmacon GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 1945 1945 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.141175821655 none Dharmacon GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 1945 1945 Viability KB cells [object Object] RSA P-value <0.001 0.225175135 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 1945 1945 Viability KB cells [object Object] RSA P-value <0.001 0.664624152 none GR00378-A Poliovirus vaccine production 26581994 1945 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -1.417211385 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 1945 NM_005227 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 23.47 Decreased viability Final hit GR00381-A-2 Regulation of mammary epithelial cell growth (2) 25572802 1945 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 34.18809111495938 none Final hit; Plasma Membrane; kinase GR00381-A-3 Regulation of mammary epithelial cell growth (3) 25572802 1945 Viability 184-hTERT-E11 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 24.620279146141215 Decreased viability Final hit; Plasma Membrane; kinase GR00386-A-1 NOD2 stimulation by MDP 25170077 1945 1945 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 108.133489385918 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 1945 1945 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -88.9 none GR00396-S Mammosphere formation and maintenance 24229464 1945 NM_005227.2 shRNA quantification SUM149 p-value <0.01 0.8774842287885483 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 1945 1945 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-006858-01 Z-score >=5.13 0.98 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 1945 1945 The percentage of infected cells A549 SIR0001964 Z-score > 5 -3.162198888112741 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 1945 1945 The percentage of infected cells A549 SIR0001964 Z-score > -3 0.3498772452475858 no effect 5 days post-infection