Stable Id	Screen title	Pubmed Id	Entrez Id	Author-provided gene Id	Assay	Biomodel	Reagent Id	Score type	Score cutoff	Score	Phenotype	Comment
GR00184-A-1	Self-renewal and pluripotency in human embryonic stem cells (1)	20953172	22863	XM_375080	POU5F1 protein expression	hESC H1	M-020438-00	Z-score	< -2	-1.06270537173787	none	
GR00165-A	HeLa cell morphology	20531400	22863	NM_014924	Cell morphology	HeLa	M-020438-00	Complex, sp	np	np	Lamellipodia cells	
GR00196-A-1	TP53 interactions (1)	21642980	22863	ENSG00000126775	TP53 protein expression and viability	HCT116 ( wildtype and TP53 knockout)	np	Complex, sp	Complex criteria	sp	none	
GR00151-A-1	Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	20613862	22863	ENSG00000126775	(HR-DSBR) DR-GFP reporter	HeLa	np	Z-score	< -2 OR > 2	0.769	none	
GR00180-A-1	Hepatitis C virus replication (1)	19286138	22863	22863	HCV replicon RNA copy number	Huh7/Rep-Feo	PL-50054	q-value	Complex criteria	0.911	none	
GR00054-A	Combinatorial effect with paclitaxel	17429401	22863	XM_375080	Viability (synthetic lethal)	NCI-H1155	np	Paclitaxel/control ratio	Complex criteria	0.922	none	
GR00056-A	Melanogenesis	19057677	22863	XM_375080	Melanin protein expression and viability	MNT-1	np	Normalized absorbance ratio	> 2 standard deviations below mean	1.052	none	
GR00098-A-2	Cell division (2)	17994010	22863	ENSG00000126775	Cell number and DNA content	HeLa	ENSG00000126775_2	Complex, sp	Complex criteria	sp	none	
GR00098-A-3	Cell division (3)	17994010	22863	ENSG00000126775	Histone H3 phosphorylation; alpha-tubulin and pericentrin protein expression	HeLa	ENSG00000126775	Mitotic index	>= 2	5.3	Increased number of mitotic cells	
GR00098-A-4	Cell division (4)	17994010	22863	ENSG00000126775	Cell size (forward scatter)	HeLa	ENSG00000126775	Cell size	>= 2	-1	none	
GR00098-A-1	Cell division (1)	17994010	22863	ENSG00000126775	Cell number and DNA content	HeLa	ENSG00000126775	Complex, sp	Complex criteria	sp	Increased G1 DNA content	G0/1 arrest, validated with resynthesized esiRNA
GR00197-A-1	Human papillomavirus oncogene expression regulation (1)	20133580	22863	22863	HPV18 LCR reporter activity	C33A/BE2/18LCR c4	M-020438-00	Z-score	>= 2	-0.020650061	none	
GR00053-A	Genome stability	19647519	22863	XM_375080	gamma-H2AX phosphorylation and DNA content	HeLa	np	p-value	Complex criteria	sp	none	
GR00236-A-1	Homologous recombination DNA double-strand break repair (HR-DSBR) (1)	22344029	22863	22863	(HR-DSBR) DR-GFP reporter and DNA content	DR-U2OS	M-020438-00	Relative HR ratio	< ~0.4 OR > 1.88	1.14944134846892	none	
GR00240-S-1	TRAIL-induced apoptosis (1)	24442637	22863	XM_375080	Viability	U251MG	M-020438-00	Z-score	> 4	-0.13	none	
GR00240-S-2	TRAIL-induced apoptosis (2)	24442637	22863	XM_375080	Viability (synthetic lethal)	U251MG	M-020438-00	Differential score	> 3.6 AND viability Z-score < 4	-0.23	none	Z-score -0.3825
GR00242-A-1	Selective autophagy regulation (1)	22020285	22863	XM_375080	Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression	HeLa/GFP-LC3	np	Z-score	Complex criteria	sp	none	
GR00247-A-1	Regulation of FOXO1 nuclear localization (1)	21460183	22863		EGFP-FOXO1a protein expression and DNA content	U2OS	np	Complex, sp	Complex criteria	sp	none	rank: 15746
GR00249-S	Vaccinia virus (VACV) infection	23401514	22863	22863	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	HeLa	J-020438-09	Z-score	>= 1 OR <= -1.5	1.26116	Increased vaccinia virus (VACV) infection	number of cells compared to control (%): 89.97
GR00249-S	Vaccinia virus (VACV) infection	23401514	22863	22863	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	HeLa	M-020438-01	Z-score	>= 1 OR <= -1.5	-0.53104	none	number of cells compared to control (%): 85.97
GR00249-S	Vaccinia virus (VACV) infection	23401514	22863	22863	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	HeLa	s22526	Z-score	>= 1 OR <= -1.5	-0.15644	none	number of cells compared to control (%): 100.77
GR00249-S	Vaccinia virus (VACV) infection	23401514	22863	22863	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	HeLa	s22527	Z-score	>= 1 OR <= -1.5	1.01932	Increased vaccinia virus (VACV) infection	number of cells compared to control (%): 92.53
GR00249-S	Vaccinia virus (VACV) infection	23401514	22863	22863	Vaccinia virus VACV IHD-J/GFP protein expression and DNA content	HeLa	s22528	Z-score	>= 1 OR <= -1.5	-0.7869	none	number of cells compared to control (%): 95.24
GR00255-A-1	Negative genetic interactions (1)	24104479	22863	22863	shRNA abundance	HCT116	TRCN0000121630,TRCN0000142849,TRCN0000143961,TRCN0000144080,TRCN0000145367	differential Gene Activity Ranking Profile (dGARP)	< -1.0	0.641304001	none	
GR00255-A-1	Negative genetic interactions (1)	24104479	22863	11019	shRNA abundance	HCT116	TRCN0000078113,TRCN0000078114,TRCN0000078115,TRCN0000078116	differential Gene Activity Ranking Profile (dGARP)	< -1.0	0.751190666	none	
GR00255-A-2	Negative genetic interactions (2)	24104479	22863	22863	shRNA abundance	HCT116	TRCN0000121630,TRCN0000142849,TRCN0000143961,TRCN0000144080,TRCN0000145367	differential Gene Activity Ranking Profile (dGARP)	< -1.0	0.246402488	none	
GR00255-A-2	Negative genetic interactions (2)	24104479	22863	11019	shRNA abundance	HCT116	TRCN0000078113,TRCN0000078114,TRCN0000078115,TRCN0000078116	differential Gene Activity Ranking Profile (dGARP)	< -1.0	-0.141900321	none	
GR00255-A-3	Negative genetic interactions (3)	24104479	22863	11019	shRNA abundance	HCT116	TRCN0000078113,TRCN0000078114,TRCN0000078115,TRCN0000078116	differential Gene Activity Ranking Profile (dGARP)	< -1.2	0.851511212	none	
GR00255-A-3	Negative genetic interactions (3)	24104479	22863	22863	shRNA abundance	HCT116	TRCN0000121630,TRCN0000142849,TRCN0000143961,TRCN0000144080,TRCN0000145367	differential Gene Activity Ranking Profile (dGARP)	< -1.2	0.015384148	none	
GR00255-A-4	Negative genetic interactions (4)	24104479	22863	11019	shRNA abundance	HCT116	TRCN0000078113,TRCN0000078114,TRCN0000078115,TRCN0000078116	differential Gene Activity Ranking Profile (dGARP)	< -1.2	0.564112115	none	
GR00255-A-4	Negative genetic interactions (4)	24104479	22863	22863	shRNA abundance	HCT116	TRCN0000121630,TRCN0000142849,TRCN0000143961,TRCN0000144080,TRCN0000145367	differential Gene Activity Ranking Profile (dGARP)	< -1.2	0.577044736	none	
GR00255-A-5	Negative genetic interactions (5)	24104479	22863	22863	shRNA abundance	HCT116	TRCN0000121630,TRCN0000142849,TRCN0000143961,TRCN0000144080,TRCN0000145367	differential Gene Activity Ranking Profile (dGARP)	< -0.8	0.31000727	none	
GR00255-A-5	Negative genetic interactions (5)	24104479	22863	11019	shRNA abundance	HCT116	TRCN0000078113,TRCN0000078114,TRCN0000078115,TRCN0000078116	differential Gene Activity Ranking Profile (dGARP)	< -0.8	-0.782521507	none	
GR00057-A-1	Wnt/beta-catenin pathway regulation (1)	18621708	22863	XM_375080	Wnt pathway reporter	HeLa	M-020438-00	Z-score	> 4	-0.02	none	
GR00057-A-2	Wnt/beta-catenin pathway regulation (2)	18621708	22863	XM_375080	Wnt pathway reporter	HeLa	M-020438-00	Complex, SP	Complex criteria	sp	none	
GR00293-A	Combinatorial effect with paclitaxel	24860162	22863		Viability	HCC366	np	Z-score	< -2.5	-0.741	none	
GR00297-A	Glucose limitation response	24670634	22863		shRNA abundance in high and low glucose	Jurkat	TRCN0000078113	Log2 ratio	< -0.75	0.07	none	
GR00300-A	Combinatorial effect with RAF inhibitor PLX4720	23288408	22863		shRNA abundance	A375	TRCN0000145367,TRCN0000121630,TRCN0000143961,TRCN0000142849,TRCN0000144080	Number of shRNAs ranked Top1000	> 2	1	none	
GR00300-A	Combinatorial effect with RAF inhibitor PLX4720	23288408	22863		shRNA abundance	A375	TRCN0000078113,TRCN0000078115,TRCN0000078114,TRCN0000078116	Number of shRNAs ranked Top1000	> 2	0	none	
GR00303-A	Clear cell renal cell carcinoma (ccRCC) survival regulation	22362593	22863	XM_375080	Proliferation and Viability	VHL-deficient RCC4	np	Z-score	<= -3	2.64	none	
GR00310-A-1	Sindbis virus (SINV) infection (1)	24367265	22863	22863	Sindbis virus (SINV) reporter	U2OS	np	Z-score	< -3 OR > 2	-0.93	none	
GR00312-A	NOD2 pathway regulation	23322906	22863	22863	NF-kappaB reporter	HEK 293	np	Normalized percent inhibition	< -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability	50.2	none	94,7% viability
GR00313-A	TNF-alpha pathway regulation	22733992	22863	NM_014924	NFkappaB pathway reporter	HEK293T	np	Z-score	<= -2.5 plus additional filters	0.37	none	
GR00363-A	Endocytosis regulation	20190736	22863	22863	Transferrin (TF) and epidermal growth factor (EGF) subcellular localisation, DNA content	HeLa	SI00455567,22231,esi5695,SI00455581,SI00455560,SI00455574,22135	Complex, sp	Complex criteria	sp	Decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)	strong
GR00369-A	Combinatorial effect with FBW7	26354767	22863	22863	shRNA abundance	HCT116	[object Object]	Gene Activity Ranking Profile (GARP)	Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean	0.010000000000000002	none	
GR00371-A-1	Nanog expression in absence of bFGF and TGFbeta	26232226	22863	22863	NANOG expression	NANOG-GFP H1 hESC	[object Object]	Z-score	>1,25 OR >1,5 [in at least two replicates]	-0.303664530306	none	Ambion
GR00371-A-2	Nanog expression in presence of TGFbeta inhibitor	26232226	22863	ATG14	NANOG expression	NANOG-GFP H1 hESC	[object Object]	Z-score	>1,25 OR >1,5 [in at least two replicates]	-0.173590250684	none	Ambion
GR00371-A-3	Nanog expression in presence of MEK inhibitor	26232226	22863	22863	NANOG expression	NANOG-GFP H1 hESC	[object Object]	Z-score	>1,25 OR >1,5 [in at least two replicates]	0.432621258705	none	Ambion
GR00371-A-4	Nanog expression in presence of PI3K inhibitor	26232226	22863	22863	NANOG expression	NANOG-GFP H1 hESC	[object Object]	Z-score	>1,25 OR >1,5 [in at least two replicates]	0.018520171395	none	Ambion
GR00371-A-5	Nanog expression in presence of retinoic acid	26232226	22863	22863	NANOG expression	NANOG-GFP H1 hESC	[object Object]	Z-score	>1,25 OR >1,5 [in at least two replicates]	0.00584447868945	none	Ambion
GR00376-A-1	Mitigators of SS1P-induced immunotoxicity	25713356	22863	22863	Viability	KB cells	[object Object]	RSA P-value	<0.001	0.111138137	none	
GR00376-A-2	Sensitizers of SS1P-induced immunotoxicity	25713356	22863	22863	Viability	KB cells	[object Object]	RSA P-value	<0.001	0.415715928	none	
GR00378-A	Poliovirus vaccine production	26581994	22863		Infection with Attenuated Poliovirus	HEp-2C	[object Object]	Z-score	>=3	-0.021892408	none	
GR00381-A-1	Regulation of mammary epithelial cell growth (1)	25572802	22863	XM_375080	Viability	184-hTERT-L9 (mammary epithelial cells)	[object Object]	Percent growth	< 25 % AND p-value < 0.05	83.969	none	
GR00386-A-1	NOD2 stimulation by MDP	25170077	22863	22863	Viability	HEK293 stably expressing NOD2	[object Object]	Percentage growth	Decreased: <70, increased: >120	89.0176619198132	none	
GR00386-A-2	MDP-induced IL-8 secretion	25170077	22863	22863	IL-8 secretion	HEK293 stably expressing NOD2	[object Object]	Percent inhibition of IL-8 secretion	Increased: <-300, Decreased: >60	11.5	none	
GR00400-S-1	Combinatorial effect with vorinostat (1)	25977774	22863	22863	Caspase 3/7 activity	HCT116 (Vorinostat resistant subclone)	M-020438-01	Z-score	>=5.13	-0.53	none