Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 4795 NM_005007 POU5F1 protein expression hESC H1 M-012001-00 Z-score < -2 0.0970539270963786 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 4795 4795 HCV replicon RNA copy number Huh7/Rep-Feo PL-50023 q-value Complex criteria 0.927 none GR00054-A Combinatorial effect with paclitaxel 17429401 4795 NM_005007 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 1.023 none GR00056-A Melanogenesis 19057677 4795 NM_005007 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.885 none GR00098-A-1 Cell division (1) 17994010 4795 ENSG00000168593 Cell number and DNA content HeLa ENSG00000168593 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 4795 4795 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-012001-00 Z-score >= 2 -0.494067438 none GR00053-A Genome stability 19647519 4795 NM_005007 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 4795 4795 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-012001-00 Relative HR ratio < ~0.4 OR > 1.88 0.54441473186833 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 4795 NM_005007 Viability U251MG M-012001-00 Z-score > 4 -0.25 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 4795 NM_005007 Viability (synthetic lethal) U251MG M-012001-00 Differential score > 3.6 AND viability Z-score < 4 -1.04 none Z-score -0.9975 GR00242-A-1 Selective autophagy regulation (1) 22020285 4795 NM_005007 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00246-A Telomere protection 21760879 4795 Telomere dysfunction-induced foci (TIF) formation (53BP1 protein expression, FITC-TelC and DNA content) HeLa np Number of TIFs >= 3 np none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 4795 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 10495 GR00249-S Vaccinia virus (VACV) infection 23401514 4795 4795 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-012001-05 Z-score >= 1 OR <= -1.5 -0.44992 none number of cells compared to control (%): 81.35 GR00249-S Vaccinia virus (VACV) infection 23401514 4795 4795 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-012001-00 Z-score >= 1 OR <= -1.5 0.14697 Decreased viability number of cells compared to control (%): 45.64 GR00249-S Vaccinia virus (VACV) infection 23401514 4795 4795 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s194653 Z-score >= 1 OR <= -1.5 0.46271 none number of cells compared to control (%): 89.02 GR00249-S Vaccinia virus (VACV) infection 23401514 4795 4795 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s9517 Z-score >= 1 OR <= -1.5 -0.41903 none number of cells compared to control (%): 98.00 GR00249-S Vaccinia virus (VACV) infection 23401514 4795 4795 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s9518 Z-score >= 1 OR <= -1.5 0.0355 none number of cells compared to control (%): 90.36 GR00253-A hepcidin regulation 24385536 4795 NM_005007 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 0.393 none GR00255-A-1 Negative genetic interactions (1) 24104479 4795 4795 shRNA abundance HCT116 TRCN0000056813,TRCN0000056814,TRCN0000056815,TRCN0000056816,TRCN0000056817 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.004646016 none GR00255-A-2 Negative genetic interactions (2) 24104479 4795 4795 shRNA abundance HCT116 TRCN0000056813,TRCN0000056814,TRCN0000056815,TRCN0000056816,TRCN0000056817 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.206332469 none GR00255-A-3 Negative genetic interactions (3) 24104479 4795 4795 shRNA abundance HCT116 TRCN0000056813,TRCN0000056814,TRCN0000056815,TRCN0000056816,TRCN0000056817 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.424145098 none GR00255-A-4 Negative genetic interactions (4) 24104479 4795 4795 shRNA abundance HCT116 TRCN0000056813,TRCN0000056814,TRCN0000056815,TRCN0000056816,TRCN0000056817 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.391836154 none GR00255-A-5 Negative genetic interactions (5) 24104479 4795 4795 shRNA abundance HCT116 TRCN0000056813,TRCN0000056814,TRCN0000056815,TRCN0000056816,TRCN0000056817 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.147873339 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 4795 NM_005007 Wnt pathway reporter HeLa M-012001-00 Z-score > 4 0.62 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 4795 NM_005007 Wnt pathway reporter HeLa M-012001-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 4795 Viability HCC366 np Z-score < -2.5 -0.242 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 4795 shRNA abundance A375 TRCN0000056813,TRCN0000056814,TRCN0000056817,TRCN0000056815,TRCN0000056816 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 4795 NM_005007 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 0.38 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 4795 4795 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -0.29 none GR00312-A NOD2 pathway regulation 23322906 4795 4795 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability -6.7 none 95,3% viability GR00313-A TNF-alpha pathway regulation 22733992 4795 NM_005007 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters 1.28 none GR00318-A Huntingtin toxicity 23209424 4795 4795 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 1.207 none siRNA set: druggable genome GR00327-A Tumor formation 24292671 4795 4795 shRNA abundance SUM-149 CLL-H-022969 Z-score > 2.24 -1.808711776843491 none GR00327-A Tumor formation 24292671 4795 4795 shRNA abundance SUM-149 CLL-H-022970 Z-score > 2.24 -0.044338930047533434 none GR00327-A Tumor formation 24292671 4795 4795 shRNA abundance SUM-149 CLL-H-022968 Z-score > 2.24 -0.2754663599933681 none GR00327-A Tumor formation 24292671 4795 4795 shRNA abundance SUM-149 CLL-H-022967 Z-score > 2.24 0.1909601652163727 none GR00327-A Tumor formation 24292671 4795 4795 shRNA abundance SUM-149 CLL-H-022966 Z-score > 2.24 -1.0024165324243257 none GR00095-A p53 pathway components 15042092 4795 NM_005007 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00123-A Combinatorial effect with nutlin-3 16474381 4795 NM_005007 Viability MCF-7 152323,152321,152322 log2 ratio np np none GR00362-A Vaccinia virus (VACV) replication 2401222 4795 221331 VACV-A5eGFP expression HeLa np Z-score <= -2 OR >= 2 3.336229 Increased replication of vaccinia virus (VACV) GR00369-A Combinatorial effect with FBW7 26354767 4795 4795 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.04 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 4795 4795 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.162432138998 none Ambion GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 4795 NFKBIL1 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.198707002463 none Ambion GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 4795 4795 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.388095048067 none Ambion GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 4795 4795 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.227790517282 none Ambion GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 4795 4795 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.598436474895 none Ambion GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 4795 4795 Viability KB cells [object Object] RSA P-value <0.001 0.14154998 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 4795 4795 Viability KB cells [object Object] RSA P-value <0.001 0.747634679 none GR00378-A Poliovirus vaccine production 26581994 4795 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 1.468403392 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 4795 NM_005007 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 38.369 none GR00386-A-1 NOD2 stimulation by MDP 25170077 4795 4795 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 91.4274083008343 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 4795 4795 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -199.7 none GR00396-S Mammosphere formation and maintenance 24229464 4795 NM_005007.2 shRNA quantification SUM149 p-value <0.01 0.13721273621369157 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 4795 4795 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-012001-00 Z-score >=5.13 2.24 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 4795 4795 The percentage of infected cells A549 SIR0005951 Z-score > 5 -2.547075260986909 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 4795 4795 The percentage of infected cells A549 SIR0005951 Z-score > -3 -5.467014557171324 Decreased viability 5 days post-infection