Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00143-A tau phosphorylation 20067632 5584 Total tau and 12E8 tau protein expression H4 overexpressing 4RON tau PRKCI s1 p-value Complex criteria sp none GR00143-A tau phosphorylation 20067632 5584 Total tau and 12E8 tau protein expression H4 overexpressing 4RON tau PRKCI s2 p-value Complex criteria sp none GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 5584 NM_002740 POU5F1 protein expression hESC H1 M-004656-01 Z-score < -2 -1.46778181066526 none GR00193-A-2 Therapeutic kinase targets in neuroblastoma (2) 21289283 5584 5584 Substrate adherent cell growth KELLY PRKCI Relative growth 0.5 standard deviations below mean 0.974 none Illumina gene expression above basal level (p < 0.05) GR00193-A-3 Therapeutic kinase targets in neuroblastoma (3) 21289283 5584 5584 Substrate adherent cell growth SKNAS PRKCI Relative growth 0.5 standard deviations below mean 1.01244199826283 none Illumina gene expression above basal level (p < 0.05) GR00193-A-4 Therapeutic kinase targets in neuroblastoma (4) 21289283 5584 5584 Substrate adherent cell growth NLF PRKCI Relative growth 0.5 standard deviations below mean 1.043 none Illumina gene expression above basal level (p < 0.05) GR00193-A-1 Therapeutic kinase targets in neuroblastoma (1) 21289283 5584 5584 Substrate adherent cell growth EBC1 PRKCI Relative growth 0.5 standard deviations below mean 0.830633103529765 none Illumina gene expression above basal level (p < 0.05) GR00155-A Aryl hydrocarbon receptor (AhR) transduction pathway regulation 21479225 5584 5584 TCDD-induced CYP1A1-related EROD activity and cell viability MCF-7 PRKCI_1,PRKCI_2,PRKCI_3 Z-score Top 150 for >= 2 of 3 siRNAs AND no effect on cell proliferation np none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 309 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -126.98 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 309 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -125.4 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 311 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 68.71 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 311 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 81.77 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 110781 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 34.61 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 110781 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 22.55 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 110783 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 4.95 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 5584 5584 Smoothed protein expression htRPE 110783 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 19.15 none GR00196-A-1 TP53 interactions (1) 21642980 5584 ENSG00000163558 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00133-A-1 Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) 21407211 5584 5584 Gentamycin protection invasion assay HeLa np log2 median Complex criteria 0.038537 none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 5584 ENSG00000163558 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.436 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 5584 5584 HCV replicon RNA copy number Huh7/Rep-Feo PL-50002 q-value Complex criteria 0.91 none GR00054-A Combinatorial effect with paclitaxel 17429401 5584 NM_002740 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.942 none GR00206-A Apoptosis regulation after Chlamydia trachomatis serovar L2 infection 21824245 5584 5584 Cleaved cytokeratin-18 protein expression HeLa np p-value <= 0.05 np none GR00210-A Focal adhesion formation 19667130 5584 5584 paxillin protein expression HeLa np Z-score > 3.5 OR < -3.5 sp none GR00213-A Circadian clock regulation 19765810 5584 NM_002740 Circadian clock Bmal1 reporter U2OS np Complex, sp Complex criteria np Increased circadian period length double hit GR00056-A Melanogenesis 19057677 5584 NM_002740 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.901 none GR00098-A-1 Cell division (1) 17994010 5584 ENSG00000163558 Cell number and DNA content HeLa ENSG00000163558 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 5584 5584 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-004656-01 Z-score >= 2 -0.864644707 none GR00016-A Wnt/beta-catenin pathway regulation 19471023 5584 5584 Wnt/beta-catenin pathway reporter RKO np Z-score > 2 1.77 none GR00053-A Genome stability 19647519 5584 NM_002740 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00221-A-1 Proliferation of cells with active beta-catenin (1) 20126544 5584 Viability MCF-7 TRCN0000006038 B-score < -1 -1.24 Decreased viability GR00221-A-1 Proliferation of cells with active beta-catenin (1) 20126544 5584 Viability MCF-7 TRCN0000006037 B-score < -1 0.1 none GR00221-A-1 Proliferation of cells with active beta-catenin (1) 20126544 5584 Viability MCF-7 TRCN0000006039 B-score < -1 0.27 none GR00221-A-1 Proliferation of cells with active beta-catenin (1) 20126544 5584 Viability MCF-7 TRCN0000006041 B-score < -1 0.59 none GR00221-A-1 Proliferation of cells with active beta-catenin (1) 20126544 5584 Viability MCF-7 TRCN0000006040 B-score < -1 0.66 none GR00221-A-2 Proliferation of cells with active beta-catenin (2) 20126544 5584 Viability MDA-MB-231 TRCN0000006039 B-score < -1 -2 Decreased viability essential gene GR00221-A-2 Proliferation of cells with active beta-catenin (2) 20126544 5584 Viability MDA-MB-231 TRCN0000006038 B-score < -1 -1.12 Decreased viability essential gene GR00221-A-2 Proliferation of cells with active beta-catenin (2) 20126544 5584 Viability MDA-MB-231 TRCN0000006037 B-score < -1 0.01 none essential gene GR00221-A-2 Proliferation of cells with active beta-catenin (2) 20126544 5584 Viability MDA-MB-231 TRCN0000006040 B-score < -1 0.18 none essential gene GR00221-A-2 Proliferation of cells with active beta-catenin (2) 20126544 5584 Viability MDA-MB-231 TRCN0000006041 B-score < -1 1.81 none essential gene GR00221-A-3 Proliferation of cells with active beta-catenin (3) 20126544 5584 Viability MDA-MB-453 TRCN0000006040 B-score < -1 -1.17 Decreased viability GR00221-A-3 Proliferation of cells with active beta-catenin (3) 20126544 5584 Viability MDA-MB-453 TRCN0000006038 B-score < -1 -0.05 none GR00221-A-3 Proliferation of cells with active beta-catenin (3) 20126544 5584 Viability MDA-MB-453 TRCN0000006039 B-score < -1 0.09 none GR00221-A-3 Proliferation of cells with active beta-catenin (3) 20126544 5584 Viability MDA-MB-453 TRCN0000006037 B-score < -1 0.38 none GR00221-A-3 Proliferation of cells with active beta-catenin (3) 20126544 5584 Viability MDA-MB-453 TRCN0000006041 B-score < -1 0.75 none GR00221-A-4 Proliferation of cells with active beta-catenin (4) 20126544 5584 Viability T47D TRCN0000006038 B-score < -1 -2.6 Decreased viability essential gene GR00221-A-4 Proliferation of cells with active beta-catenin (4) 20126544 5584 Viability T47D TRCN0000006041 B-score < -1 -1.02 Decreased viability essential gene GR00221-A-4 Proliferation of cells with active beta-catenin (4) 20126544 5584 Viability T47D TRCN0000006037 B-score < -1 0.01 none essential gene GR00221-A-4 Proliferation of cells with active beta-catenin (4) 20126544 5584 Viability T47D TRCN0000006040 B-score < -1 0.16 none essential gene GR00221-A-4 Proliferation of cells with active beta-catenin (4) 20126544 5584 Viability T47D TRCN0000006039 B-score < -1 0.36 none essential gene GR00225-A Combinatorial effect with gemcitabine 19519883 5584 Viability (synthetic lethal) MIAPaCa-2 PRKCI_A log2 ratio 1.65 SD below mean ratio level -1.187261 none GR00225-A Combinatorial effect with gemcitabine 19519883 5584 Viability (synthetic lethal) MIAPaCa-2 PRKCI_B log2 ratio 1.65 SD below mean ratio level -0.734483 none GR00225-A Combinatorial effect with gemcitabine 19519883 5584 Viability (synthetic lethal) MIAPaCa-2 PRKCI_A log2 ratio 1.65 SD below mean ratio level 0.019783 none GR00225-A Combinatorial effect with gemcitabine 19519883 5584 Viability (synthetic lethal) MIAPaCa-2 PRKCI_B log2 ratio 1.65 SD below mean ratio level -0.01082 none GR00228-A TNF-induced apoptosis 20460151 5584 NM_002740 Viability (synthetic lethal) HeLa np Death index 99% confidence interval: > 2.58 SD; 95% confidence interval: > 1.96 SD 1.279733 none GR00055-A-3 Epithelial cell migration (3) 19160483 5584 5584 Cell migration and viability MCF-10A overexpressing ERBB2 np Area score and Alamar score Complex criteria np none GR00055-A-1 Epithelial cell migration (1) 19160483 5584 5584 Cell migration and viability MCF-10A np Area score and Alamar score Complex criteria np Decreased cell migration deconvoluted validated siRNAs: 0/2 GR00231-A Cell proliferation 21765947 5584 NM_002740 Viability HeLa M-004656-01 Z-score < -1.96 OR > 1.96 0.786 none GR00234-A-1 Hepatitis C virus (HCV) infection (1) 21516087 5584 NM_002740 Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) protein expression Huh7 np Complex, sp Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 5584 5584 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-004656-01 Relative HR ratio < ~0.4 OR > 1.88 1.26799290518937 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 5584 NM_002740 Viability U251MG M-004656-01 Z-score > 4 1.13 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 5584 NM_002740 Viability (synthetic lethal) U251MG M-004656-01 Differential score > 3.6 AND viability Z-score < 4 -1.33 none Z-score -0.2195 GR00242-A-1 Selective autophagy regulation (1) 22020285 5584 NM_002740 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00243-A Cdk9 T-loop phosphorylation 21448926 5584 5584 Cdk9 T-loop phosphorylation and beta-Actin protein expression HeLa 309,311,110781 np >= 2 of 3 siRNAs decreasing phosphorylation np none 1/3 siRNAs GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 5584 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 17072 GR00248-A Human cytomegalovirus (HCMV) strain AD169 replication 22315427 5584 NM_002740 Human cytomegalovirus (HCMV) IE1 protein expression MRC5 PRKCI_siRNA1 Z-score >=2 or <=-2 for >= 2 of 3 siRNA -4.143 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A Human cytomegalovirus (HCMV) strain AD169 replication 22315427 5584 NM_002740 Human cytomegalovirus (HCMV) IE1 protein expression MRC5 PRKCI_siRNA2 Z-score >=2 or <=-2 for >= 2 of 3 siRNA -0.358 none GR00248-A Human cytomegalovirus (HCMV) strain AD169 replication 22315427 5584 NM_002740 Human cytomegalovirus (HCMV) IE1 protein expression MRC5 PRKCI_siRNA3 Z-score >=2 or <=-2 for >= 2 of 3 siRNA 0.473 none GR00249-S Vaccinia virus (VACV) infection 23401514 5584 5584 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-004656-07 Z-score >= 1 OR <= -1.5 -0.71272 none number of cells compared to control (%): 77.97 GR00249-S Vaccinia virus (VACV) infection 23401514 5584 5584 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-004656-02 Z-score >= 1 OR <= -1.5 -0.50744 none number of cells compared to control (%): 92.66 GR00249-S Vaccinia virus (VACV) infection 23401514 5584 5584 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s11110 Z-score >= 1 OR <= -1.5 -2.22304 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 73.91 GR00249-S Vaccinia virus (VACV) infection 23401514 5584 5584 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s11111 Z-score >= 1 OR <= -1.5 1.16061 Increased vaccinia virus (VACV) infection number of cells compared to control (%): 75.36 GR00249-S Vaccinia virus (VACV) infection 23401514 5584 5584 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s11112 Z-score >= 1 OR <= -1.5 -1.83575 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 72.00 GR00253-A hepcidin regulation 24385536 5584 NM_002740 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 1.096 none GR00255-A-1 Negative genetic interactions (1) 24104479 5584 91662 shRNA abundance HCT116 TRCN0000107105,TRCN0000107106,TRCN0000107107,TRCN0000107108,TRCN0000107109 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.67073734 none GR00255-A-1 Negative genetic interactions (1) 24104479 5584 5584 shRNA abundance HCT116 TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040,TRCN0000006041 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.353881561 none GR00255-A-2 Negative genetic interactions (2) 24104479 5584 91662 shRNA abundance HCT116 TRCN0000107105,TRCN0000107106,TRCN0000107107,TRCN0000107108,TRCN0000107109 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.408107388 none GR00255-A-2 Negative genetic interactions (2) 24104479 5584 5584 shRNA abundance HCT116 TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040,TRCN0000006041 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.186185826 none GR00255-A-3 Negative genetic interactions (3) 24104479 5584 91662 shRNA abundance HCT116 TRCN0000107105,TRCN0000107106,TRCN0000107107,TRCN0000107108,TRCN0000107109 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.234306902 none GR00255-A-3 Negative genetic interactions (3) 24104479 5584 5584 shRNA abundance HCT116 TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040,TRCN0000006041 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.055010411 none GR00255-A-4 Negative genetic interactions (4) 24104479 5584 91662 shRNA abundance HCT116 TRCN0000107105,TRCN0000107106,TRCN0000107107,TRCN0000107108,TRCN0000107109 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.978296435 none GR00255-A-4 Negative genetic interactions (4) 24104479 5584 5584 shRNA abundance HCT116 TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040,TRCN0000006041 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.552172591 none GR00255-A-5 Negative genetic interactions (5) 24104479 5584 91662 shRNA abundance HCT116 TRCN0000107105,TRCN0000107106,TRCN0000107107,TRCN0000107108,TRCN0000107109 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.292648285 none GR00255-A-5 Negative genetic interactions (5) 24104479 5584 5584 shRNA abundance HCT116 TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040,TRCN0000006041 differential Gene Activity Ranking Profile (dGARP) < -0.8 0.101928887 none GR00256-A Kinase-mediated spindle orientation 22252550 5584 NM_002740 beta-tubulin protein expression and DNA content HeLa np Complex, sp Complex criteria sp none GR00107-A-1 Apoptosis regulation 17012250 5584 NM002740 Viability (histone protein expression and cytoplasmic DNA content) MiaPaCa-2 np Fold change Complex criteria 2 Decreased viability GR00107-A-2 Combinatioral effect with gemcitabine 17012250 5584 NM002740 Viability (histone protein expression and cytoplasmic DNA content) MiaPaCa-2 np Fold change Complex criteria 1.6 Decreased viability after gemcitabine stimulation GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 5584 NM_002740 Wnt pathway reporter HeLa M-004656-01 Z-score > 4 -0.69 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 5584 NM_002740 Wnt pathway reporter HeLa M-004656-01 Complex, SP Complex criteria sp none GR00114-A Combinatorial effect with Poly (ADP‐ribose)‐polymerase‐1 (PARP) 18388863 5584 Viability CAL51 np Z-score <= -3 -0.37 none 72% GR00293-A Combinatorial effect with paclitaxel 24860162 5584 Viability HCC366 np Z-score < -2.5 -0.028 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 5584 shRNA abundance A375 TRCN0000107109,TRCN0000107108,TRCN0000107107,TRCN0000107106,TRCN0000107105 Number of shRNAs ranked Top1000 > 2 0 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 5584 shRNA abundance A375 TRCN0000006041,TRCN0000006037,TRCN0000006038,TRCN0000006039,TRCN0000006040 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 5584 NM_002740 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -0.86 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 5584 5584 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -1.42 none GR00312-A NOD2 pathway regulation 23322906 5584 5584 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 34 none 98,3% viability GR00313-A TNF-alpha pathway regulation 22733992 5584 NM_002740 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -1.36 none GR00318-A Huntingtin toxicity 23209424 5584 5584 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 0.777 none siRNA set: kinase GR00095-A p53 pathway components 15042092 5584 NM_002740 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00342-S-1 Viability of Mesenchymal Stem Cells (MSC) (1) 26120366 5584 Viability Bone marrow derived MSC M-004656-01 Z-score >= 1.5 OR <= -1.5 0.37821374527837215 none GR00342-S-2 Viability of Mesenchymal Stem Cells (MSC) (2) 26120366 5584 Viability Bone marrow derived MSC M-004656-01 Z-score >= 1.5 OR <= -1.5 0.3664995999199884 none GR00342-S-3 Viability of Mesenchymal Stem Cells (MSC) (3) 26120366 5584 Viability Bone marrow derived MSC M-004656-01 Z-score >= 1.5 OR <= -1.5 0.4676856759511661 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 5584 5584 shRNA abundance K562 TRCN0000006040 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.3199999999999985 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 5584 5584 shRNA abundance K562 TRCN0000006037 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.5175 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 5584 5584 shRNA abundance K562 TRCN0000006038 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.0599999999999987 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 5584 5584 shRNA abundance K562 TRCN0000006041 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.5099999999999998 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 5584 5584 shRNA abundance K562 TRCN0000006039 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.0024999999999995026 none GR00123-A Combinatorial effect with nutlin-3 16474381 5584 NM_002740 Viability MCF-7 100552,100551,100553 log2 ratio np np none GR00355-A PIP3-mediated epidermal growth factor (EGFR) endocytosis 24425787 5584 5584 Epidermal growth factor (EGFR) surface abundance HeLa Kyoto np Deviation score < -1 OR > 1 np none GR00356-A-1 Clathrin-mediated endocytosis 15889048 5584 NM_002740 Vesicular stomatitis virus (VSV) infection (rVSV–GFP expression) HeLa np Relative infection index (RII) <= 0.33 OR >= 3.00 0.72 none GR00356-A-2 Caveolin- and lipid raft-mediated endocytosis 15889048 5584 NM_002740 Simian virus 40 (SV40) infection (SV40 large T-antigen expression) HeLa np Relative infection index (RII) <= 0.33 OR >= 3 0.8732669607776453 none GR00356-A-3 Endocytosis regulation 15889048 5584 NM_002740 Transferrin (Tfn) uptake and trafficking HeLa np np np np none GR00360-A-1 Secretory transport (1) 22660414 5584 ENSG00000163558 CFP-tsO45G cell surface transport HeLa Kyoto 311 Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) 0.8401500000000001 Mildly decreased CFP-tsO45G cell surface transport GR00366-A-1 Context-specific genetic dependencies (1) 25984343 5584 shRNA abundance 22RV1_PROSTATE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.533251088196259 none PRKCI_1_10101 GR00366-A-2 Context-specific genetic dependencies (2) 25984343 5584 shRNA abundance 697_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.236228208863825 none PRKCI_1_10101 GR00366-A-3 Context-specific genetic dependencies (3) 25984343 5584 shRNA abundance 786O_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.69224194090897 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-4 Context-specific genetic dependencies (4) 25984343 5584 shRNA abundance A1207_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.326982818979724 none PRKCI_1_10101 GR00366-A-5 Context-specific genetic dependencies (5) 25984343 5584 shRNA abundance A172_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.573287223161953 none PRKCI_1_10101 GR00366-A-6 Context-specific genetic dependencies (6) 25984343 5584 shRNA abundance A204_SOFT_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.778497683593353 none PRKCI_1_10101 GR00366-A-7 Context-specific genetic dependencies (7) 25984343 5584 shRNA abundance A2058_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.422772280810068 none PRKCI_1_10101 GR00366-A-8 Context-specific genetic dependencies (8) 25984343 5584 shRNA abundance A549_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.307525981582574 none PRKCI_1_10101 GR00366-A-9 Context-specific genetic dependencies (9) 25984343 5584 shRNA abundance A673_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.249790667848111 none PRKCI_1_10101 GR00366-A-10 Context-specific genetic dependencies (10) 25984343 5584 shRNA abundance ACHN_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.785414355162641 none PRKCI_1_10101 GR00366-A-11 Context-specific genetic dependencies (11) 25984343 5584 shRNA abundance AGS_STOMACH TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -2.15000849805397 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-12 Context-specific genetic dependencies (12) 25984343 5584 shRNA abundance AM38_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.766866387979769 none PRKCI_1_10101 GR00366-A-13 Context-specific genetic dependencies (13) 25984343 5584 shRNA abundance AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0781243871845339 none PRKCI_1_10101 GR00366-A-14 Context-specific genetic dependencies (14) 25984343 5584 shRNA abundance ASPC1_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.64259675261151 none PRKCI_1_10101 GR00366-A-15 Context-specific genetic dependencies (15) 25984343 5584 shRNA abundance BT20_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.64442829413895 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-16 Context-specific genetic dependencies (16) 25984343 5584 shRNA abundance BT474_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.459166545444588 none PRKCI_1_10101 GR00366-A-17 Context-specific genetic dependencies (17) 25984343 5584 shRNA abundance BXPC3_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0536181444786885 none PRKCI_1_10101 GR00366-A-18 Context-specific genetic dependencies (18) 25984343 5584 shRNA abundance C2BBE1_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.963656594513412 none PRKCI_1_10101 GR00366-A-19 Context-specific genetic dependencies (19) 25984343 5584 shRNA abundance C32_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.180850801100158 none PRKCI_1_10101 GR00366-A-20 Context-specific genetic dependencies (20) 25984343 5584 shRNA abundance CADOES1_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.569745060091018 none PRKCI_1_10101 GR00366-A-21 Context-specific genetic dependencies (21) 25984343 5584 shRNA abundance CAL120_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.20861797044022 none PRKCI_1_10101 GR00366-A-22 Context-specific genetic dependencies (22) 25984343 5584 shRNA abundance CAL51_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.804799498926503 none PRKCI_1_10101 GR00366-A-23 Context-specific genetic dependencies (23) 25984343 5584 shRNA abundance CALU1_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.413964391415552 none PRKCI_1_10101 GR00366-A-24 Context-specific genetic dependencies (24) 25984343 5584 shRNA abundance CAOV3_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.11055150337853 none PRKCI_1_10101 GR00366-A-25 Context-specific genetic dependencies (25) 25984343 5584 shRNA abundance CAOV4_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.25490966654038 none PRKCI_1_10101 GR00366-A-26 Context-specific genetic dependencies (26) 25984343 5584 shRNA abundance CAS1_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.330767657644665 none PRKCI_1_10101 GR00366-A-27 Context-specific genetic dependencies (27) 25984343 5584 shRNA abundance CFPAC1_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.19430443412285 none PRKCI_1_10101 GR00366-A-28 Context-specific genetic dependencies (28) 25984343 5584 shRNA abundance CH157MN_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.291007395604356 none PRKCI_1_10101 GR00366-A-29 Context-specific genetic dependencies (29) 25984343 5584 shRNA abundance COLO205_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.306090647002634 none PRKCI_1_10101 GR00366-A-30 Context-specific genetic dependencies (30) 25984343 5584 shRNA abundance COLO704_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.57627757961567 Increased shRNA abundance (Z-score > 2) PRKCI_1_10101 GR00366-A-31 Context-specific genetic dependencies (31) 25984343 5584 shRNA abundance COLO741_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.21298101180024 none PRKCI_1_10101 GR00366-A-32 Context-specific genetic dependencies (32) 25984343 5584 shRNA abundance COLO783_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.471492178550565 none PRKCI_1_10101 GR00366-A-33 Context-specific genetic dependencies (33) 25984343 5584 shRNA abundance CORL23_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.58319549654707 Increased shRNA abundance (Z-score > 2) PRKCI_1_10101 GR00366-A-34 Context-specific genetic dependencies (34) 25984343 5584 shRNA abundance COV362_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.22983474845536 none PRKCI_1_10101 GR00366-A-35 Context-specific genetic dependencies (35) 25984343 5584 shRNA abundance COV434_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.387154752160008 none PRKCI_1_10101 GR00366-A-36 Context-specific genetic dependencies (36) 25984343 5584 shRNA abundance COV504_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.186986895127664 none PRKCI_1_10101 GR00366-A-37 Context-specific genetic dependencies (37) 25984343 5584 shRNA abundance COV644_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.14763432074004 none PRKCI_1_10101 GR00366-A-38 Context-specific genetic dependencies (38) 25984343 5584 shRNA abundance DBTRG05MG_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.938809054577408 none PRKCI_1_10101 GR00366-A-39 Context-specific genetic dependencies (39) 25984343 5584 shRNA abundance DKMG_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.128523475941998 none PRKCI_1_10101 GR00366-A-40 Context-specific genetic dependencies (40) 25984343 5584 shRNA abundance DLD1_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.60284206902473 Increased shRNA abundance (Z-score > 2) PRKCI_1_10101 GR00366-A-41 Context-specific genetic dependencies (41) 25984343 5584 shRNA abundance EFE184_ENDOMETRIUM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.284151137701251 none PRKCI_1_10101 GR00366-A-42 Context-specific genetic dependencies (42) 25984343 5584 shRNA abundance EFM19_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.511224074352651 none PRKCI_1_10101 GR00366-A-43 Context-specific genetic dependencies (43) 25984343 5584 shRNA abundance EFO21_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0591347181062251 none PRKCI_1_10101 GR00366-A-44 Context-specific genetic dependencies (44) 25984343 5584 shRNA abundance EFO27_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.325879888284179 none PRKCI_1_10101 GR00366-A-45 Context-specific genetic dependencies (45) 25984343 5584 shRNA abundance EW8_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.17299692282213 none PRKCI_1_10101 GR00366-A-46 Context-specific genetic dependencies (46) 25984343 5584 shRNA abundance EWS502_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.23092266656497 none PRKCI_1_10101 GR00366-A-47 Context-specific genetic dependencies (47) 25984343 5584 shRNA abundance F36P_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.602288909346578 none PRKCI_1_10101 GR00366-A-48 Context-specific genetic dependencies (48) 25984343 5584 shRNA abundance GB1_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0375343431608602 none PRKCI_1_10101 GR00366-A-49 Context-specific genetic dependencies (49) 25984343 5584 shRNA abundance GP2D_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.667304968581891 none PRKCI_1_10101 GR00366-A-50 Context-specific genetic dependencies (50) 25984343 5584 shRNA abundance HCC1187_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.566240038878706 none PRKCI_1_10101 GR00366-A-51 Context-specific genetic dependencies (51) 25984343 5584 shRNA abundance HCC1395_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.716144244019633 none PRKCI_1_10101 GR00366-A-52 Context-specific genetic dependencies (52) 25984343 5584 shRNA abundance HCC1954_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0902691560651821 none PRKCI_1_10101 GR00366-A-53 Context-specific genetic dependencies (53) 25984343 5584 shRNA abundance HCC2218_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.369048731042215 none PRKCI_1_10101 GR00366-A-54 Context-specific genetic dependencies (54) 25984343 5584 shRNA abundance HCC2814_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.170788130125008 none PRKCI_1_10101 GR00366-A-55 Context-specific genetic dependencies (55) 25984343 5584 shRNA abundance HCC364_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0127407542983587 none PRKCI_1_10101 GR00366-A-56 Context-specific genetic dependencies (56) 25984343 5584 shRNA abundance HCC44_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.62344987807161 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-57 Context-specific genetic dependencies (57) 25984343 5584 shRNA abundance HCC70_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.749933744858158 none PRKCI_1_10101 GR00366-A-58 Context-specific genetic dependencies (58) 25984343 5584 shRNA abundance HCC827GR5_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.33458775146978 none PRKCI_1_10101 GR00366-A-59 Context-specific genetic dependencies (59) 25984343 5584 shRNA abundance HCC827_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.405665881028977 none PRKCI_1_10101 GR00366-A-60 Context-specific genetic dependencies (60) 25984343 5584 shRNA abundance HCT116_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.06004536419556 none PRKCI_1_10101 GR00366-A-61 Context-specific genetic dependencies (61) 25984343 5584 shRNA abundance HEC1A_ENDOMETRIUM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.365803397544029 none PRKCI_1_10101 GR00366-A-62 Context-specific genetic dependencies (62) 25984343 5584 shRNA abundance HEYA8_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.514000798100925 none PRKCI_1_10101 GR00366-A-63 Context-specific genetic dependencies (63) 25984343 5584 shRNA abundance HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.440588524849708 none PRKCI_1_10101 GR00366-A-64 Context-specific genetic dependencies (64) 25984343 5584 shRNA abundance HLF_LIVER TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.814888394145173 none PRKCI_1_10101 GR00366-A-65 Context-specific genetic dependencies (65) 25984343 5584 shRNA abundance HNT34_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.647801364586614 none PRKCI_1_10101 GR00366-A-66 Context-specific genetic dependencies (66) 25984343 5584 shRNA abundance HPAC_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.05059270697788 none PRKCI_1_10101 GR00366-A-67 Context-specific genetic dependencies (67) 25984343 5584 shRNA abundance HPAFII_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.42934378010559 none PRKCI_1_10101 GR00366-A-68 Context-specific genetic dependencies (68) 25984343 5584 shRNA abundance HS683_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.140350417147425 none PRKCI_1_10101 GR00366-A-69 Context-specific genetic dependencies (69) 25984343 5584 shRNA abundance HS766T_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.428180475995064 none PRKCI_1_10101 GR00366-A-70 Context-specific genetic dependencies (70) 25984343 5584 shRNA abundance HS944T_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.384350101052299 none PRKCI_1_10101 GR00366-A-71 Context-specific genetic dependencies (71) 25984343 5584 shRNA abundance HT1197_URINARY_TRACT TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.336508697594187 none PRKCI_1_10101 GR00366-A-72 Context-specific genetic dependencies (72) 25984343 5584 shRNA abundance HT29_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.01020569460065 none PRKCI_1_10101 GR00366-A-73 Context-specific genetic dependencies (73) 25984343 5584 shRNA abundance HT55_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.82712833636786 none PRKCI_1_10101 GR00366-A-74 Context-specific genetic dependencies (74) 25984343 5584 shRNA abundance HUG1N_STOMACH TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.1951953115067 none PRKCI_1_10101 GR00366-A-75 Context-specific genetic dependencies (75) 25984343 5584 shRNA abundance HUTU80_SMALL_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.153864225167461 none PRKCI_1_10101 GR00366-A-76 Context-specific genetic dependencies (76) 25984343 5584 shRNA abundance IGR39_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.25224065687516 none PRKCI_1_10101 GR00366-A-77 Context-specific genetic dependencies (77) 25984343 5584 shRNA abundance IGROV1_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.373730435625304 none PRKCI_1_10101 GR00366-A-78 Context-specific genetic dependencies (78) 25984343 5584 shRNA abundance IOMMLEE_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.262859319226917 none PRKCI_1_10101 GR00366-A-79 Context-specific genetic dependencies (79) 25984343 5584 shRNA abundance JHESOAD1_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.280909121759338 none PRKCI_1_10101 GR00366-A-80 Context-specific genetic dependencies (80) 25984343 5584 shRNA abundance JHOC5_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.57369846872646 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-81 Context-specific genetic dependencies (81) 25984343 5584 shRNA abundance JHOM1_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.644175837420411 none PRKCI_1_10101 GR00366-A-82 Context-specific genetic dependencies (82) 25984343 5584 shRNA abundance JJN3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.0334503741257 none PRKCI_1_10101 GR00366-A-83 Context-specific genetic dependencies (83) 25984343 5584 shRNA abundance K562_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.836015856487609 none PRKCI_1_10101 GR00366-A-84 Context-specific genetic dependencies (84) 25984343 5584 shRNA abundance KALS1_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.26447956071975 none PRKCI_1_10101 GR00366-A-85 Context-specific genetic dependencies (85) 25984343 5584 shRNA abundance KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 2.20388356541338 Increased shRNA abundance (Z-score > 2) PRKCI_1_10101 GR00366-A-86 Context-specific genetic dependencies (86) 25984343 5584 shRNA abundance KM12_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.450979969376832 none PRKCI_1_10101 GR00366-A-87 Context-specific genetic dependencies (87) 25984343 5584 shRNA abundance KMS12BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.87415245575296 Increased shRNA abundance (Z-score > 2) PRKCI_1_10101 GR00366-A-88 Context-specific genetic dependencies (88) 25984343 5584 shRNA abundance KNS60_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.207381600881637 none PRKCI_1_10101 GR00366-A-89 Context-specific genetic dependencies (89) 25984343 5584 shRNA abundance KNS81_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.243377362706492 none PRKCI_1_10101 GR00366-A-90 Context-specific genetic dependencies (90) 25984343 5584 shRNA abundance KP1NL_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.364228823415631 none PRKCI_1_10101 GR00366-A-91 Context-specific genetic dependencies (91) 25984343 5584 shRNA abundance KP2_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0813871434913814 none PRKCI_1_10101 GR00366-A-92 Context-specific genetic dependencies (92) 25984343 5584 shRNA abundance KP4_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.09340802056431 none PRKCI_1_10101 GR00366-A-93 Context-specific genetic dependencies (93) 25984343 5584 shRNA abundance KURAMOCHI_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.101167855683908 none PRKCI_1_10101 GR00366-A-94 Context-specific genetic dependencies (94) 25984343 5584 shRNA abundance KYSE150_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.511545501153352 none PRKCI_1_10101 GR00366-A-95 Context-specific genetic dependencies (95) 25984343 5584 shRNA abundance KYSE30_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.377165572780136 none PRKCI_1_10101 GR00366-A-96 Context-specific genetic dependencies (96) 25984343 5584 shRNA abundance KYSE450_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.297007130490086 none PRKCI_1_10101 GR00366-A-97 Context-specific genetic dependencies (97) 25984343 5584 shRNA abundance KYSE510_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0592432065107504 none PRKCI_1_10101 GR00366-A-98 Context-specific genetic dependencies (98) 25984343 5584 shRNA abundance L33_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.290742496332267 none PRKCI_1_10101 GR00366-A-99 Context-specific genetic dependencies (99) 25984343 5584 shRNA abundance L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.891193643109085 none PRKCI_1_10101 GR00366-A-100 Context-specific genetic dependencies (100) 25984343 5584 shRNA abundance LAMA84_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.02977821406644 none PRKCI_1_10101 GR00366-A-101 Context-specific genetic dependencies (101) 25984343 5584 shRNA abundance LK2_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.767917850507153 none PRKCI_1_10101 GR00366-A-102 Context-specific genetic dependencies (102) 25984343 5584 shRNA abundance LN215_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.536212964135311 none PRKCI_1_10101 GR00366-A-103 Context-specific genetic dependencies (103) 25984343 5584 shRNA abundance LN229_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.722945808792656 none PRKCI_1_10101 GR00366-A-104 Context-specific genetic dependencies (104) 25984343 5584 shRNA abundance LN235_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.08960984520243 none PRKCI_1_10101 GR00366-A-105 Context-specific genetic dependencies (105) 25984343 5584 shRNA abundance LN319_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.119886610668768 none PRKCI_1_10101 GR00366-A-106 Context-specific genetic dependencies (106) 25984343 5584 shRNA abundance LN340_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.272005417516887 none PRKCI_1_10101 GR00366-A-107 Context-specific genetic dependencies (107) 25984343 5584 shRNA abundance LN382_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.719926474338931 none PRKCI_1_10101 GR00366-A-108 Context-specific genetic dependencies (108) 25984343 5584 shRNA abundance LN428_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.72405484561523 none PRKCI_1_10101 GR00366-A-109 Context-specific genetic dependencies (109) 25984343 5584 shRNA abundance LN443_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.225358908816452 none PRKCI_1_10101 GR00366-A-110 Context-specific genetic dependencies (110) 25984343 5584 shRNA abundance LN464_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.176623730337654 none PRKCI_1_10101 GR00366-A-111 Context-specific genetic dependencies (111) 25984343 5584 shRNA abundance LNZ308_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.312543615298794 none PRKCI_1_10101 GR00366-A-112 Context-specific genetic dependencies (112) 25984343 5584 shRNA abundance LOVO_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.10728489396496 none PRKCI_1_10101 GR00366-A-113 Context-specific genetic dependencies (113) 25984343 5584 shRNA abundance LS411N_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.229158243723318 none PRKCI_1_10101 GR00366-A-114 Context-specific genetic dependencies (114) 25984343 5584 shRNA abundance LS513_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0737042530341449 none PRKCI_1_10101 GR00366-A-115 Context-specific genetic dependencies (115) 25984343 5584 shRNA abundance MCF7_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.997329926703483 none PRKCI_1_10101 GR00366-A-116 Context-specific genetic dependencies (116) 25984343 5584 shRNA abundance MDAMB453_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.320497180138164 none PRKCI_1_10101 GR00366-A-117 Context-specific genetic dependencies (117) 25984343 5584 shRNA abundance MIAPACA2_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.01117462572835 none PRKCI_1_10101 GR00366-A-118 Context-specific genetic dependencies (118) 25984343 5584 shRNA abundance MKN7_STOMACH TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.24979941062962 none PRKCI_1_10101 GR00366-A-119 Context-specific genetic dependencies (119) 25984343 5584 shRNA abundance MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.322530118072597 none PRKCI_1_10101 GR00366-A-120 Context-specific genetic dependencies (120) 25984343 5584 shRNA abundance MOLM13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.103601782065378 none PRKCI_1_10101 GR00366-A-121 Context-specific genetic dependencies (121) 25984343 5584 shRNA abundance MONOMAC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.130919927174456 none PRKCI_1_10101 GR00366-A-122 Context-specific genetic dependencies (122) 25984343 5584 shRNA abundance MONOMAC6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.397547568475167 none PRKCI_1_10101 GR00366-A-123 Context-specific genetic dependencies (123) 25984343 5584 shRNA abundance MV411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.693494177483623 none PRKCI_1_10101 GR00366-A-124 Context-specific genetic dependencies (124) 25984343 5584 shRNA abundance NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.329108785238373 none PRKCI_1_10101 GR00366-A-125 Context-specific genetic dependencies (125) 25984343 5584 shRNA abundance NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.220984487451587 none PRKCI_1_10101 GR00366-A-126 Context-specific genetic dependencies (126) 25984343 5584 shRNA abundance NCIH1299_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0131576703242953 none PRKCI_1_10101 GR00366-A-127 Context-specific genetic dependencies (127) 25984343 5584 shRNA abundance NCIH1437_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.984663714380664 none PRKCI_1_10101 GR00366-A-128 Context-specific genetic dependencies (128) 25984343 5584 shRNA abundance NCIH1650_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.278244922551942 none PRKCI_1_10101 GR00366-A-129 Context-specific genetic dependencies (129) 25984343 5584 shRNA abundance NCIH1792_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.53834006318707 none PRKCI_1_10101 GR00366-A-130 Context-specific genetic dependencies (130) 25984343 5584 shRNA abundance NCIH196_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.169307890745849 none PRKCI_1_10101 GR00366-A-131 Context-specific genetic dependencies (131) 25984343 5584 shRNA abundance NCIH1975_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.25297000954132 none PRKCI_1_10101 GR00366-A-132 Context-specific genetic dependencies (132) 25984343 5584 shRNA abundance NCIH2052_PLEURA TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0676090286239252 none PRKCI_1_10101 GR00366-A-133 Context-specific genetic dependencies (133) 25984343 5584 shRNA abundance NCIH2122_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.322515401622436 none PRKCI_1_10101 GR00366-A-134 Context-specific genetic dependencies (134) 25984343 5584 shRNA abundance NCIH2171_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.245926243311813 none PRKCI_1_10101 GR00366-A-135 Context-specific genetic dependencies (135) 25984343 5584 shRNA abundance NCIH23_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.307309229902004 none PRKCI_1_10101 GR00366-A-136 Context-specific genetic dependencies (136) 25984343 5584 shRNA abundance NCIH2452_PLEURA TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.644847341193345 none PRKCI_1_10101 GR00366-A-137 Context-specific genetic dependencies (137) 25984343 5584 shRNA abundance NCIH441_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.894082333604742 none PRKCI_1_10101 GR00366-A-138 Context-specific genetic dependencies (138) 25984343 5584 shRNA abundance NCIH508_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.34780276369911 none PRKCI_1_10101 GR00366-A-139 Context-specific genetic dependencies (139) 25984343 5584 shRNA abundance NCIH660_PROSTATE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.230070769714348 none PRKCI_1_10101 GR00366-A-140 Context-specific genetic dependencies (140) 25984343 5584 shRNA abundance NCIH661_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.123085745590636 none PRKCI_1_10101 GR00366-A-141 Context-specific genetic dependencies (141) 25984343 5584 shRNA abundance NCIH716_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.31751923896758 none PRKCI_1_10101 GR00366-A-142 Context-specific genetic dependencies (142) 25984343 5584 shRNA abundance NCIH838_LUNG TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.13276011279769 none PRKCI_1_10101 GR00366-A-143 Context-specific genetic dependencies (143) 25984343 5584 shRNA abundance NCIN87_STOMACH TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.381412610656061 none PRKCI_1_10101 GR00366-A-144 Context-specific genetic dependencies (144) 25984343 5584 shRNA abundance NIHOVCAR3_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.155706726486854 none PRKCI_1_10101 GR00366-A-145 Context-specific genetic dependencies (145) 25984343 5584 shRNA abundance NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0547659889632781 none PRKCI_1_10101 GR00366-A-146 Context-specific genetic dependencies (146) 25984343 5584 shRNA abundance OAW42_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -2.31236878675999 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-147 Context-specific genetic dependencies (147) 25984343 5584 shRNA abundance OCIAML2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.311156698459363 none PRKCI_1_10101 GR00366-A-148 Context-specific genetic dependencies (148) 25984343 5584 shRNA abundance OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0960011442535721 none PRKCI_1_10101 GR00366-A-149 Context-specific genetic dependencies (149) 25984343 5584 shRNA abundance OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.47005277719985 none PRKCI_1_10101 GR00366-A-150 Context-specific genetic dependencies (150) 25984343 5584 shRNA abundance OE33_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0958712245677146 none PRKCI_1_10101 GR00366-A-151 Context-specific genetic dependencies (151) 25984343 5584 shRNA abundance OELE_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.853268211683687 none PRKCI_1_10101 GR00366-A-152 Context-specific genetic dependencies (152) 25984343 5584 shRNA abundance OPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.395184146624964 none PRKCI_1_10101 GR00366-A-153 Context-specific genetic dependencies (153) 25984343 5584 shRNA abundance OV7_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.00314047599821951 none PRKCI_1_10101 GR00366-A-154 Context-specific genetic dependencies (154) 25984343 5584 shRNA abundance OV90_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.768788721318667 none PRKCI_1_10101 GR00366-A-155 Context-specific genetic dependencies (155) 25984343 5584 shRNA abundance OVCAR4_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.922570520927364 none PRKCI_1_10101 GR00366-A-156 Context-specific genetic dependencies (156) 25984343 5584 shRNA abundance OVCAR8_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.653996840765307 none PRKCI_1_10101 GR00366-A-157 Context-specific genetic dependencies (157) 25984343 5584 shRNA abundance OVISE_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.112722878805099 none PRKCI_1_10101 GR00366-A-158 Context-specific genetic dependencies (158) 25984343 5584 shRNA abundance PANC0327_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.96104223956065 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-159 Context-specific genetic dependencies (159) 25984343 5584 shRNA abundance PANC0813_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.982022431977214 none PRKCI_1_10101 GR00366-A-160 Context-specific genetic dependencies (160) 25984343 5584 shRNA abundance PANC1005_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.25426490298924 none PRKCI_1_10101 GR00366-A-161 Context-specific genetic dependencies (161) 25984343 5584 shRNA abundance PLB985_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.128397517233905 none PRKCI_1_10101 GR00366-A-162 Context-specific genetic dependencies (162) 25984343 5584 shRNA abundance PSN1_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.892397175891158 none PRKCI_1_10101 GR00366-A-163 Context-specific genetic dependencies (163) 25984343 5584 shRNA abundance QGP1_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.518852640451064 none PRKCI_1_10101 GR00366-A-164 Context-specific genetic dependencies (164) 25984343 5584 shRNA abundance REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.558609774721199 none PRKCI_1_10101 GR00366-A-165 Context-specific genetic dependencies (165) 25984343 5584 shRNA abundance RKN_SOFT_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.900435837864031 none PRKCI_1_10101 GR00366-A-166 Context-specific genetic dependencies (166) 25984343 5584 shRNA abundance RKO_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.26414037151246 none PRKCI_1_10101 GR00366-A-167 Context-specific genetic dependencies (167) 25984343 5584 shRNA abundance RMGI_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.269134365841594 none PRKCI_1_10101 GR00366-A-168 Context-specific genetic dependencies (168) 25984343 5584 shRNA abundance RMUGS_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0879481541374835 none PRKCI_1_10101 GR00366-A-169 Context-specific genetic dependencies (169) 25984343 5584 shRNA abundance RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.824924472666367 none PRKCI_1_10101 GR00366-A-170 Context-specific genetic dependencies (170) 25984343 5584 shRNA abundance RT112_URINARY_TRACT TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.107262343162574 none PRKCI_1_10101 GR00366-A-171 Context-specific genetic dependencies (171) 25984343 5584 shRNA abundance SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.428092853111784 none PRKCI_1_10101 GR00366-A-172 Context-specific genetic dependencies (172) 25984343 5584 shRNA abundance SF126_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.495561051434772 none PRKCI_1_10101 GR00366-A-173 Context-specific genetic dependencies (173) 25984343 5584 shRNA abundance SF172_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.73911288491914 Decreased shRNA abundance (Z-score < -2) PRKCI_1_10101 GR00366-A-174 Context-specific genetic dependencies (174) 25984343 5584 shRNA abundance SF295_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.913249797694915 none PRKCI_1_10101 GR00366-A-175 Context-specific genetic dependencies (175) 25984343 5584 shRNA abundance SF767_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.10980384351925 none PRKCI_1_10101 GR00366-A-176 Context-specific genetic dependencies (176) 25984343 5584 shRNA abundance SJSA1_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0738150520226868 none PRKCI_1_10101 GR00366-A-177 Context-specific genetic dependencies (177) 25984343 5584 shRNA abundance SKCO1_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.359318293303419 none PRKCI_1_10101 GR00366-A-178 Context-specific genetic dependencies (178) 25984343 5584 shRNA abundance SKMEL5_SKIN TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.221686815472504 none PRKCI_1_10101 GR00366-A-179 Context-specific genetic dependencies (179) 25984343 5584 shRNA abundance SKMM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.978535335565153 none PRKCI_1_10101 GR00366-A-180 Context-specific genetic dependencies (180) 25984343 5584 shRNA abundance SKNO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.793342033064814 none PRKCI_1_10101 GR00366-A-181 Context-specific genetic dependencies (181) 25984343 5584 shRNA abundance SKOV3_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.832610268596302 none PRKCI_1_10101 GR00366-A-182 Context-specific genetic dependencies (182) 25984343 5584 shRNA abundance SKRC20_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.176778666081272 none PRKCI_1_10101 GR00366-A-183 Context-specific genetic dependencies (183) 25984343 5584 shRNA abundance SLR20_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.70920629288088 none PRKCI_1_10101 GR00366-A-184 Context-specific genetic dependencies (184) 25984343 5584 shRNA abundance SLR21_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.0818831005823945 none PRKCI_1_10101 GR00366-A-185 Context-specific genetic dependencies (185) 25984343 5584 shRNA abundance SLR23_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.34399865812546 none PRKCI_1_10101 GR00366-A-186 Context-specific genetic dependencies (186) 25984343 5584 shRNA abundance SLR24_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.776884251800585 none PRKCI_1_10101 GR00366-A-187 Context-specific genetic dependencies (187) 25984343 5584 shRNA abundance SLR25_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.07156452621671 none PRKCI_1_10101 GR00366-A-188 Context-specific genetic dependencies (188) 25984343 5584 shRNA abundance SLR26_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.296432561064266 none PRKCI_1_10101 GR00366-A-189 Context-specific genetic dependencies (189) 25984343 5584 shRNA abundance SNU1105_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.47025866404266 none PRKCI_1_10101 GR00366-A-190 Context-specific genetic dependencies (190) 25984343 5584 shRNA abundance SNU840_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.425131253285105 none PRKCI_1_10101 GR00366-A-191 Context-specific genetic dependencies (191) 25984343 5584 shRNA abundance SNUC1_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.619573666506076 none PRKCI_1_10101 GR00366-A-192 Context-specific genetic dependencies (192) 25984343 5584 shRNA abundance SNUC2A_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.00875018025442 none PRKCI_1_10101 GR00366-A-193 Context-specific genetic dependencies (193) 25984343 5584 shRNA abundance SU8686_PANCREAS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.568966464936427 none PRKCI_1_10101 GR00366-A-194 Context-specific genetic dependencies (194) 25984343 5584 shRNA abundance SW1417_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.239034788709902 none PRKCI_1_10101 GR00366-A-195 Context-specific genetic dependencies (195) 25984343 5584 shRNA abundance SW1783_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.267017402935002 none PRKCI_1_10101 GR00366-A-196 Context-specific genetic dependencies (196) 25984343 5584 shRNA abundance SW480_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.41722892255549 none PRKCI_1_10101 GR00366-A-197 Context-specific genetic dependencies (197) 25984343 5584 shRNA abundance SW48_LARGE_INTESTINE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.04263927143036 none PRKCI_1_10101 GR00366-A-198 Context-specific genetic dependencies (198) 25984343 5584 shRNA abundance T98G_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.438455111231997 none PRKCI_1_10101 GR00366-A-199 Context-specific genetic dependencies (199) 25984343 5584 shRNA abundance TC71_BONE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.36104871252752 none PRKCI_1_10101 GR00366-A-200 Context-specific genetic dependencies (200) 25984343 5584 shRNA abundance TCCSUP_URINARY_TRACT TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.487029070850886 none PRKCI_1_10101 GR00366-A-201 Context-specific genetic dependencies (201) 25984343 5584 shRNA abundance TE10_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.287154582990975 none PRKCI_1_10101 GR00366-A-202 Context-specific genetic dependencies (202) 25984343 5584 shRNA abundance TE15_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.925048568021882 none PRKCI_1_10101 GR00366-A-203 Context-specific genetic dependencies (203) 25984343 5584 shRNA abundance TE9_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.15899141580171 none PRKCI_1_10101 GR00366-A-204 Context-specific genetic dependencies (204) 25984343 5584 shRNA abundance THP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0141100756370389 none PRKCI_1_10101 GR00366-A-205 Context-specific genetic dependencies (205) 25984343 5584 shRNA abundance TOV112D_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.10456896546776 none PRKCI_1_10101 GR00366-A-206 Context-specific genetic dependencies (206) 25984343 5584 shRNA abundance TOV21G_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0500432960396122 none PRKCI_1_10101 GR00366-A-207 Context-specific genetic dependencies (207) 25984343 5584 shRNA abundance TT_OESOPHAGUS TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.171002671702482 none PRKCI_1_10101 GR00366-A-208 Context-specific genetic dependencies (208) 25984343 5584 shRNA abundance TYKNU_OVARY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.693693987725391 none PRKCI_1_10101 GR00366-A-209 Context-specific genetic dependencies (209) 25984343 5584 shRNA abundance U178_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.319155244382841 none PRKCI_1_10101 GR00366-A-210 Context-specific genetic dependencies (210) 25984343 5584 shRNA abundance U251MG_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.395152369647921 none PRKCI_1_10101 GR00366-A-211 Context-specific genetic dependencies (211) 25984343 5584 shRNA abundance U343_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.457415675922122 none PRKCI_1_10101 GR00366-A-212 Context-specific genetic dependencies (212) 25984343 5584 shRNA abundance U87MG_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.414889109924327 none PRKCI_1_10101 GR00366-A-213 Context-specific genetic dependencies (213) 25984343 5584 shRNA abundance UOK101_KIDNEY TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -1.31124237399613 none PRKCI_1_10101 GR00366-A-214 Context-specific genetic dependencies (214) 25984343 5584 shRNA abundance VCAP_PROSTATE TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) -0.413966711160126 none PRKCI_1_10101 GR00366-A-215 Context-specific genetic dependencies (215) 25984343 5584 shRNA abundance YKG1_CENTRAL_NERVOUS_SYSTEM TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 1.10858642889034 none PRKCI_1_10101 GR00366-A-216 Context-specific genetic dependencies (216) 25984343 5584 shRNA abundance ZR7530_BREAST TRCN0000220636,TRCN0000220637,TRCN0000344667 Fold change np (default cutoff applied: Z-score > 2 OR < -2) 0.0174612193603116 none PRKCI_1_10101 GR00369-A Combinatorial effect with FBW7 26354767 5584 5584 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.09999999999999999 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 5584 5584 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.788321571726 none Dharmacon GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 5584 PRKCI NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.272575884494 none Dharmacon GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 5584 5584 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.423222638686 none Dharmacon GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 5584 5584 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.573470051034 none Dharmacon GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 5584 5584 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.138260307725 none Dharmacon GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 5584 5584 Viability KB cells [object Object] RSA P-value <0.001 0.136857568 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 5584 5584 Viability KB cells [object Object] RSA P-value <0.001 0.270172268 none GR00378-A Poliovirus vaccine production 26581994 5584 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -1.455186857 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 5584 NM_002740 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 94.413 none GR00386-A-1 NOD2 stimulation by MDP 25170077 5584 5584 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 83.6885603191225 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 5584 5584 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -40.9 none GR00396-S Mammosphere formation and maintenance 24229464 5584 NM_002740.5 shRNA quantification SUM149 p-value <0.01 0.0012298415039535202 Reduced mammosphere formation Reduced adherent proliferation GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 5584 5584 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-004656-02 Z-score >=5.13 -0.6 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 5584 5584 The percentage of infected cells A549 SIR0007039 Z-score > 5 -2.1617333447066787 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 5584 5584 The percentage of infected cells A549 SIR0007039 Z-score > -3 -0.684300689754288 no effect 5 days post-infection