Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 56975 NM_020223 POU5F1 protein expression hESC H1 M-013791-00 Z-score < -2 -0.34075312272035 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 56975 56975 HCV replicon RNA copy number Huh7/Rep-Feo PL-50062 q-value Complex criteria 0.746 none GR00054-A Combinatorial effect with paclitaxel 17429401 56975 NM_020223 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.785 none GR00056-A Melanogenesis 19057677 56975 NM_020223 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 1.2 none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 56975 56975 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-013791-00 Z-score >= 2 0.215737375 none GR00053-A Genome stability 19647519 56975 NM_020223 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 56975 56975 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-013791-00 Relative HR ratio < ~0.4 OR > 1.88 0.835754262050264 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 56975 NM_020223 Viability U251MG M-013791-00 Z-score > 4 -1.46 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 56975 NM_020223 Viability (synthetic lethal) U251MG M-013791-00 Differential score > 3.6 AND viability Z-score < 4 0.3 none Z-score -0.9365 GR00242-A-1 Selective autophagy regulation (1) 22020285 56975 NM_020223 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 56975 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 9932 GR00249-S Vaccinia virus (VACV) infection 23401514 56975 56975 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-013791-09 Z-score >= 1 OR <= -1.5 -1.2229 none number of cells compared to control (%): 92.20 GR00249-S Vaccinia virus (VACV) infection 23401514 56975 56975 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-013791-01 Z-score >= 1 OR <= -1.5 -1.05993 none number of cells compared to control (%): 77.55 GR00249-S Vaccinia virus (VACV) infection 23401514 56975 56975 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s226900 Z-score >= 1 OR <= -1.5 0.06327 none number of cells compared to control (%): 96.45 GR00249-S Vaccinia virus (VACV) infection 23401514 56975 56975 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s32510 Z-score >= 1 OR <= -1.5 0.2301 none number of cells compared to control (%): 100.06 GR00249-S Vaccinia virus (VACV) infection 23401514 56975 56975 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s32511 Z-score >= 1 OR <= -1.5 0.32706 none number of cells compared to control (%): 82.87 GR00253-A hepcidin regulation 24385536 56975 NM_020223 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 0.82 none GR00255-A-1 Negative genetic interactions (1) 24104479 56975 56975 shRNA abundance HCT116 TRCN0000127525,TRCN0000128164,TRCN0000128300,TRCN0000128442,TRCN0000129247 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.00295134 none GR00255-A-2 Negative genetic interactions (2) 24104479 56975 56975 shRNA abundance HCT116 TRCN0000127525,TRCN0000128164,TRCN0000128300,TRCN0000128442,TRCN0000129247 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.125901317 none GR00255-A-3 Negative genetic interactions (3) 24104479 56975 56975 shRNA abundance HCT116 TRCN0000127525,TRCN0000128164,TRCN0000128300,TRCN0000128442,TRCN0000129247 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.987046075 none GR00255-A-4 Negative genetic interactions (4) 24104479 56975 56975 shRNA abundance HCT116 TRCN0000127525,TRCN0000128164,TRCN0000128300,TRCN0000128442,TRCN0000129247 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.617724412 none GR00255-A-5 Negative genetic interactions (5) 24104479 56975 56975 shRNA abundance HCT116 TRCN0000127525,TRCN0000128164,TRCN0000128300,TRCN0000128442,TRCN0000129247 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.223151325 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 56975 NM_020223 Wnt pathway reporter HeLa M-013791-00 Z-score > 4 -0.87 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 56975 NM_020223 Wnt pathway reporter HeLa M-013791-00 Complex, SP Complex criteria sp Downregulation of Wnt pathway after Wnt3A stimulation GR00293-A Combinatorial effect with paclitaxel 24860162 56975 Viability HCC366 np Z-score < -2.5 -0.542 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 56975 shRNA abundance A375 TRCN0000128442,TRCN0000129247,TRCN0000127525,TRCN0000128164,TRCN0000128300 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 56975 NM_020223 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -0.14 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 56975 56975 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -0.19 none GR00312-A NOD2 pathway regulation 23322906 56975 56975 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 36.2 none 61,2% viability GR00313-A TNF-alpha pathway regulation 22733992 56975 NM_020223 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters 1.39 none GR00360-A-1 Secretory transport (1) 22660414 56975 ENSG00000177706 CFP-tsO45G cell surface transport HeLa Kyoto 242876 Deviation score < - 1 OR > 0.75 (mild: 0.75 - 1.0; strong: > 1.0) np No cells GR00369-A Combinatorial effect with FBW7 26354767 56975 56975 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean 0.04 none GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 56975 56975 Viability KB cells [object Object] RSA P-value <0.001 0.122423474 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 56975 56975 Viability KB cells [object Object] RSA P-value <0.001 0.43987225 none GR00378-A Poliovirus vaccine production 26581994 56975 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 0.115626268 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 56975 NM_020223 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 14.404 Decreased viability GR00381-A-2 Regulation of mammary epithelial cell growth (2) 25572802 56975 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 28.346876248834423 none Extracellular Space; other GR00381-A-3 Regulation of mammary epithelial cell growth (3) 25572802 56975 Viability 184-hTERT-E11 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 25.974958949096884 none Extracellular Space; other GR00386-A-1 NOD2 stimulation by MDP 25170077 56975 56975 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 61.1164381067645 Decreased viability GR00386-A-2 MDP-induced IL-8 secretion 25170077 56975 56975 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -313.3 Increased IL-8 secretion GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 56975 56975 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-013791-01 Z-score >=5.13 -0.74 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 56975 56975 The percentage of infected cells A549 SIR0012153 Z-score > 5 -4.146326261575377 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 56975 56975 The percentage of infected cells A549 SIR0012153 Z-score > -3 0.7918754013967906 no effect 5 days post-infection