Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 56998 NM_020248 POU5F1 protein expression hESC H1 M-020881-00 Z-score < -2 -2.03417288469294 Decreased POU5F1-GFP protein expression GR00196-A-1 TP53 interactions (1) 21642980 56998 ENSG00000178585 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00133-A-1 Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) 21407211 56998 56998 Gentamycin protection invasion assay HeLa np log2 median Complex criteria -0.345145 none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 56998 ENSG00000178585 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.711 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 56998 56998 HCV replicon RNA copy number Huh7/Rep-Feo PL-50006 q-value Complex criteria 0.915 none GR00054-A Combinatorial effect with paclitaxel 17429401 56998 NM_020248 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.922 none GR00056-A Melanogenesis 19057677 56998 NM_020248 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 1.027 none GR00098-A-1 Cell division (1) 17994010 56998 ENSG00000178585 Cell number and DNA content HeLa ENSG00000178585 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 56998 56998 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-020881-00 Z-score >= 2 0.534386273 none GR00016-A Wnt/beta-catenin pathway regulation 19471023 56998 56998 Wnt/beta-catenin pathway reporter RKO np Z-score > 2 0.53 none GR00053-A Genome stability 19647519 56998 NM_020248 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 56998 56998 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-020881-00 Relative HR ratio < ~0.4 OR > 1.88 0.563896804949445 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 56998 NM_020248 Viability U251MG M-020881-00 Z-score > 4 0.58 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 56998 NM_020248 Viability (synthetic lethal) U251MG M-020881-00 Differential score > 3.6 AND viability Z-score < 4 -0.07 none Z-score 0.6195 GR00242-A-1 Selective autophagy regulation (1) 22020285 56998 NM_020248 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00244-A Combinatorial effect with neratinib 21487605 56998 Viability (synthetic lethal) SKBR-3 overexpressing ErbB2 np Fold change <= -2 OR >= 2 -2.36 Decreased viability with neratinib GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 56998 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 17321 GR00249-S Vaccinia virus (VACV) infection 23401514 56998 56998 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-020881-05 Z-score >= 1 OR <= -1.5 -0.28691 none number of cells compared to control (%): 91.84 GR00249-S Vaccinia virus (VACV) infection 23401514 56998 56998 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-020881-01 Z-score >= 1 OR <= -1.5 -0.23047 none number of cells compared to control (%): 63.53 GR00249-S Vaccinia virus (VACV) infection 23401514 56998 56998 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s226901 Z-score >= 1 OR <= -1.5 0.62003 none number of cells compared to control (%): 87.08 GR00249-S Vaccinia virus (VACV) infection 23401514 56998 56998 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s32564 Z-score >= 1 OR <= -1.5 -0.72342 none number of cells compared to control (%): 97.97 GR00249-S Vaccinia virus (VACV) infection 23401514 56998 56998 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s32565 Z-score >= 1 OR <= -1.5 -1.08441 none number of cells compared to control (%): 79.95 GR00251-A-1 Non-small cell lung cancer (NSCLC) cytotoxicity (1) 24040035 56998 shRNA abundance A549 np Complex, sp Complex criteria -1 Decreased shRNA abundance GR00251-A-2 Non-small cell lung cancer (NSCLC) cytotoxicity (2) 24040035 56998 shRNA abundance NCI-H460 np Complex, sp Complex criteria -2 Decreased shRNA abundance GR00253-A hepcidin regulation 24385536 56998 NM_020248 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 0.692 none GR00255-A-1 Negative genetic interactions (1) 24104479 56998 56998 shRNA abundance HCT116 TRCN0000021829,TRCN0000021830,TRCN0000021831,TRCN0000021832 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.131302689 none GR00255-A-2 Negative genetic interactions (2) 24104479 56998 56998 shRNA abundance HCT116 TRCN0000021829,TRCN0000021830,TRCN0000021831,TRCN0000021832 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.910685526 none GR00255-A-3 Negative genetic interactions (3) 24104479 56998 56998 shRNA abundance HCT116 TRCN0000021829,TRCN0000021830,TRCN0000021831,TRCN0000021832 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.278786784 none GR00255-A-4 Negative genetic interactions (4) 24104479 56998 56998 shRNA abundance HCT116 TRCN0000021829,TRCN0000021830,TRCN0000021831,TRCN0000021832 differential Gene Activity Ranking Profile (dGARP) < -1.2 1.096658334 none GR00255-A-5 Negative genetic interactions (5) 24104479 56998 56998 shRNA abundance HCT116 TRCN0000021829,TRCN0000021830,TRCN0000021831,TRCN0000021832 differential Gene Activity Ranking Profile (dGARP) < -0.8 -0.493992436 none GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 56998 NM_020248 Wnt pathway reporter HeLa M-020881-00 Z-score > 4 1.16 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 56998 NM_020248 Wnt pathway reporter HeLa M-020881-00 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 56998 Viability HCC366 np Z-score < -2.5 -0.688 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 56998 shRNA abundance A375 TRCN0000021830,TRCN0000021829,TRCN0000021832,TRCN0000021831 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 56998 NM_020248 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 0.43 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 56998 56998 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 0.96 none GR00312-A NOD2 pathway regulation 23322906 56998 56998 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 37.2 none 84,4% viability GR00313-A TNF-alpha pathway regulation 22733992 56998 NM_001012329,NM_020248 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -1.14 none GR00318-A Huntingtin toxicity 23209424 56998 56998 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 0.927 none siRNA set: druggable genome GR00095-A p53 pathway components 15042092 56998 NM_020248 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 56998 56998 shRNA abundance K562 TRCN0000021832 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.4599999999999991 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 56998 56998 shRNA abundance K562 TRCN0000021830 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.5724999999999998 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 56998 56998 shRNA abundance K562 TRCN0000021829 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.0299999999999994 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 56998 56998 shRNA abundance K562 TRCN0000021831 Log2 ratio <= -2 (shRNA abundance <= 25%) -3.342500000000001 shRNA abundance <= 25% GR00123-A Combinatorial effect with nutlin-3 16474381 56998 NM_020248 Viability MCF-7 128573,128571,128572 log2 ratio np np none GR00369-A Combinatorial effect with FBW7 26354767 56998 56998 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean 0.12 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 56998 56998 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.783032214617 none Ambion GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 56998 CTNNBIP1 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -2.07190926003 none Ambion GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 56998 56998 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -2.29852599353 none Ambion GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 56998 56998 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -2.30221940412 none Ambion GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 56998 56998 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -1.6255140231 none Ambion GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 56998 56998 Viability KB cells [object Object] RSA P-value <0.001 0.83695568 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 56998 56998 Viability KB cells [object Object] RSA P-value <0.001 0.066967743 none GR00378-A Poliovirus vaccine production 26581994 56998 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -0.405304753 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 56998 NM_020248 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 111.583 none GR00386-A-1 NOD2 stimulation by MDP 25170077 56998 56998 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 85.4627620349718 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 56998 56998 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -106.7 none GR00396-S Mammosphere formation and maintenance 24229464 56998 NM_020248.2 shRNA quantification SUM149 p-value <0.01 0.6195760057812658 none Reduced adherent proliferation GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 56998 56998 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-020881-01 Z-score >=5.13 0.91 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 56998 56998 The percentage of infected cells A549 SIR0000566 Z-score > 5 -3.2530862571885573 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 56998 56998 The percentage of infected cells A549 SIR0000566 Z-score > -3 -0.6477751580092729 no effect 5 days post-infection