Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 638 NM_001197 POU5F1 protein expression hESC H1 M-004388-01 Z-score < -2 -0.961944797569152 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 6408 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 4.12 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 6408 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -6.05 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120202 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 4.37 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120202 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 17.18 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120785 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -14.35 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120785 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -38.36 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120786 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean -5.4 none GR00149-A-1 Ciliogenesis and cilium length (1) 20393563 638 638 Smoothed protein expression htRPE 120786 Normalized percent inhibition > 1.5 OR < -1.5 standard deviations from mean 11.44 none GR00196-A-1 TP53 interactions (1) 21642980 638 ENSG00000100290 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00133-A-1 Salmonella enterica subspecies 1 serovar Typhimurium invasion (1) 21407211 638 638 Gentamycin protection invasion assay HeLa np log2 median Complex criteria 0.035069 none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 638 ENSG00000100290 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.198 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 638 638 HCV replicon RNA copy number Huh7/Rep-Feo PL-50020 q-value Complex criteria 0.897 none GR00054-A Combinatorial effect with paclitaxel 17429401 638 NM_001197 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.932 none GR00206-A Apoptosis regulation after Chlamydia trachomatis serovar L2 infection 21824245 638 638 Cleaved cytokeratin-18 protein expression HeLa np p-value <= 0.05 np none GR00056-A Melanogenesis 19057677 638 NM_001197 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 1.022 none GR00098-A-1 Cell division (1) 17994010 638 ENSG00000100290 Cell number and DNA content HeLa ENSG00000100290 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 638 638 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-004388-01 Z-score >= 2 0.162142934 none GR00053-A Genome stability 19647519 638 NM_001197 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 638 638 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-004388-01 Relative HR ratio < ~0.4 OR > 1.88 1.13599760915374 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 638 NM_001197 Viability U251MG M-004388-01 Z-score > 4 0.39 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 638 NM_001197 Viability (synthetic lethal) U251MG M-004388-01 Differential score > 3.6 AND viability Z-score < 4 0.54 none Z-score 1.1435 GR00242-A-1 Selective autophagy regulation (1) 22020285 638 NM_001197 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria sp none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 638 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 9612 GR00249-S Vaccinia virus (VACV) infection 23401514 638 638 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-004388-10 Z-score >= 1 OR <= -1.5 -1.12108 none number of cells compared to control (%): 89.95 GR00249-S Vaccinia virus (VACV) infection 23401514 638 638 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-004388-02 Z-score >= 1 OR <= -1.5 -1.24762 none number of cells compared to control (%): 50.55 GR00249-S Vaccinia virus (VACV) infection 23401514 638 638 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s1988 Z-score >= 1 OR <= -1.5 0.56895 none number of cells compared to control (%): 84.18 GR00249-S Vaccinia virus (VACV) infection 23401514 638 638 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s1989 Z-score >= 1 OR <= -1.5 -1.20969 none number of cells compared to control (%): 87.44 GR00249-S Vaccinia virus (VACV) infection 23401514 638 638 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s1990 Z-score >= 1 OR <= -1.5 -0.73977 none number of cells compared to control (%): 89.77 GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 638 638 Viability (synthetic lethal) A375 D-004388-06 Complex, sp Complex criteria sp Increased viability with MLN4924 (a NAE inhibitor) sextuplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 638 638 Viability (synthetic lethal) A375 D-004388-07 Complex, sp Complex criteria sp Synthetic lethal with MLN4924 (a NAE inhibitor) sextuplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 638 638 Viability (synthetic lethal) A375 D-004388-08 Complex, sp Complex criteria sp Synthetic lethal with MLN4924 (a NAE inhibitor) sextuplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 638 638 Viability (synthetic lethal) A375 D-004388-09 Complex, sp Complex criteria sp Synthetic lethal with MLN4924 (a NAE inhibitor) sextuplicate screen GR00253-A hepcidin regulation 24385536 638 NM_001197 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 0.683 none GR00255-A-1 Negative genetic interactions (1) 24104479 638 638 shRNA abundance HCT116 TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527,TRCN0000033528 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.755925308 none GR00255-A-2 Negative genetic interactions (2) 24104479 638 638 shRNA abundance HCT116 TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527,TRCN0000033528 differential Gene Activity Ranking Profile (dGARP) < -1.0 -0.25549088 none GR00255-A-3 Negative genetic interactions (3) 24104479 638 638 shRNA abundance HCT116 TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527,TRCN0000033528 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.663604336 none GR00255-A-4 Negative genetic interactions (4) 24104479 638 638 shRNA abundance HCT116 TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527,TRCN0000033528 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.941579733 none GR00255-A-5 Negative genetic interactions (5) 24104479 638 638 shRNA abundance HCT116 TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527,TRCN0000033528 differential Gene Activity Ranking Profile (dGARP) < -0.8 1.051439512 none GR00250-A-1 Combinatorial effect with MLN4924, a NAE inhibitor (1) 23100467 638 638 Viability (synthetic lethal) A375 M-004388-01 Complex, sp Complex criteria sp Increased viability with MLN4924 (a NAE inhibitor) duplicate screen GR00257-A-1 Cell division, migration and survival (1) 20360735 638 H2B-GFP protein expression HeLa 120785 Complex, sp Complex criteria sp Increased viability (proliferation) GR00099-A Mitotic spindle integrity 18302737 638 638 Histone H3 phosphorylation, alpha-tubulin protein expression and DNA content HeLa GNF109988 Mitotic index >= 3 standard deviations above mean 0.77 Mitotic spindle defects hit based on OPI clustering GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 638 NM_001197 Wnt pathway reporter HeLa M-004388-01 Z-score > 4 -0.24 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 638 NM_001197 Wnt pathway reporter HeLa M-004388-01 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 638 Viability HCC366 np Z-score < -2.5 -0.752 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 638 shRNA abundance A375 TRCN0000033528,TRCN0000033524,TRCN0000033525,TRCN0000033526,TRCN0000033527 Number of shRNAs ranked Top1000 > 2 0 none GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 638 NM_001197 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 0.86 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 638 638 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 -0.2 none GR00312-A NOD2 pathway regulation 23322906 638 638 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 62.8 Decreased NF-kappaB reporter expression 84,1% viability GR00313-A TNF-alpha pathway regulation 22733992 638 NM_001197 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters -0.68 none GR00318-A Huntingtin toxicity 23209424 638 638 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 1.228 none siRNA set: druggable genome GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020402 Z-score > 2.24 0.4592004132849181 none GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020403 Z-score > 2.24 -1.400186055453959 none GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020401 Z-score > 2.24 -0.09105538299099931 none GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020404 Z-score > 2.24 np none GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020400 Z-score > 2.24 -1.2319233142632064 none GR00327-A Tumor formation 24292671 638 638 shRNA abundance SUM-149 CLL-H-020405 Z-score > 2.24 0.30210284271295745 none GR00095-A p53 pathway components 15042092 638 NM_001197 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 638 638 shRNA abundance K562 TRCN0000033527 Log2 ratio <= -2 (shRNA abundance <= 25%) 1.4275000000000002 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 638 638 shRNA abundance K562 TRCN0000033528 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.10000000000000142 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 638 638 shRNA abundance K562 TRCN0000033524 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.9274999999999984 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 638 638 shRNA abundance K562 TRCN0000033526 Log2 ratio <= -2 (shRNA abundance <= 25%) -1.6000000000000014 shRNA abundance <= 50% GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 638 638 shRNA abundance K562 TRCN0000033525 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.8975000000000009 none GR00123-A Combinatorial effect with nutlin-3 16474381 638 NM_001197 Viability MCF-7 111833,111832,111831 log2 ratio np np none GR00369-A Combinatorial effect with FBW7 26354767 638 638 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean 0 none GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 638 638 Viability KB cells [object Object] RSA P-value <0.001 0.18764554 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 638 638 Viability KB cells [object Object] RSA P-value <0.001 0.290143542 none GR00378-A Poliovirus vaccine production 26581994 638 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 0.391305598 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 638 NM_001197 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 49.322 none GR00386-A-1 NOD2 stimulation by MDP 25170077 638 638 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 79.6545590436086 none GR00386-A-2 MDP-induced IL-8 secretion 25170077 638 638 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 45.6 none GR00396-S Mammosphere formation and maintenance 24229464 638 NM_001197.3 shRNA quantification SUM149 p-value <0.01 0.008846807542240107 Reduced mammosphere formation Reduced adherent proliferation GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 638 638 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-004388-02 Z-score >=5.13 -0.02 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 638 638 The percentage of infected cells A549 SIR0005178 Z-score > 5 -1.3689292791990137 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 638 638 The percentage of infected cells A549 SIR0005178 Z-score > -3 -0.5597575872627581 no effect 5 days post-infection