Stable Id Screen title Pubmed Id Entrez Id Author-provided gene Id Assay Biomodel Reagent Id Score type Score cutoff Score Phenotype Comment GR00184-A-1 Self-renewal and pluripotency in human embryonic stem cells (1) 20953172 7544 NM_003411 POU5F1 protein expression hESC H1 M-006573-01 Z-score < -2 -1.26912069149333 none GR00196-A-1 TP53 interactions (1) 21642980 7544 ENSG00000067646 TP53 protein expression and viability HCT116 ( wildtype and TP53 knockout) np Complex, sp Complex criteria sp none GR00151-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 20613862 7544 ENSG00000067646 (HR-DSBR) DR-GFP reporter HeLa np Z-score < -2 OR > 2 0.42 none GR00180-A-1 Hepatitis C virus replication (1) 19286138 7544 7544 HCV replicon RNA copy number Huh7/Rep-Feo PL-50010 q-value Complex criteria 0.833 none GR00054-A Combinatorial effect with paclitaxel 17429401 7544 NM_003411 Viability (synthetic lethal) NCI-H1155 np Paclitaxel/control ratio Complex criteria 0.852 none GR00056-A Melanogenesis 19057677 7544 NM_003411 Melanin protein expression and viability MNT-1 np Normalized absorbance ratio > 2 standard deviations below mean 0.881 none GR00098-A-1 Cell division (1) 17994010 7544 ENSG00000067646 Cell number and DNA content HeLa ENSG00000067646 Complex, sp Complex criteria sp none GR00197-A-1 Human papillomavirus oncogene expression regulation (1) 20133580 7544 7544 HPV18 LCR reporter activity C33A/BE2/18LCR c4 M-006573-01 Z-score >= 2 1.726957363 none GR00053-A Genome stability 19647519 7544 NM_003411 gamma-H2AX phosphorylation and DNA content HeLa np p-value Complex criteria sp none GR00236-A-1 Homologous recombination DNA double-strand break repair (HR-DSBR) (1) 22344029 7544 7544 (HR-DSBR) DR-GFP reporter and DNA content DR-U2OS M-006573-01 Relative HR ratio < ~0.4 OR > 1.88 1.27614394331886 none GR00240-S-1 TRAIL-induced apoptosis (1) 24442637 7544 NM_003411 Viability U251MG M-006573-01 Z-score > 4 0.82 none GR00240-S-2 TRAIL-induced apoptosis (2) 24442637 7544 NM_003411 Viability (synthetic lethal) U251MG M-006573-01 Differential score > 3.6 AND viability Z-score < 4 -1.53 none Z-score -0.673 GR00242-A-1 Selective autophagy regulation (1) 22020285 7544 NM_003411 Sindbis virus (SIN) capsid SIN-mCherry.capsid and autophagosome GFP–LC3 protein expression HeLa/GFP-LC3 np Z-score Complex criteria np none GR00247-A-1 Regulation of FOXO1 nuclear localization (1) 21460183 7544 EGFP-FOXO1a protein expression and DNA content U2OS np Complex, sp Complex criteria sp none rank: 18174 GR00249-S Vaccinia virus (VACV) infection 23401514 7544 7544 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa J-006573-06 Z-score >= 1 OR <= -1.5 -2.26399 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 72.08 GR00249-S Vaccinia virus (VACV) infection 23401514 7544 7544 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa M-006573-01 Z-score >= 1 OR <= -1.5 -0.56963 none number of cells compared to control (%): 67.87 GR00249-S Vaccinia virus (VACV) infection 23401514 7544 7544 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s14992 Z-score >= 1 OR <= -1.5 -0.37522 none number of cells compared to control (%): 80.59 GR00249-S Vaccinia virus (VACV) infection 23401514 7544 7544 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s14993 Z-score >= 1 OR <= -1.5 -2.33746 Decreased vaccinia virus (VACV) infection number of cells compared to control (%): 80.21 GR00249-S Vaccinia virus (VACV) infection 23401514 7544 7544 Vaccinia virus VACV IHD-J/GFP protein expression and DNA content HeLa s14994 Z-score >= 1 OR <= -1.5 -0.10386 none number of cells compared to control (%): 100.69 GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 7544 7544 Viability (synthetic lethal) A375 D-006573-01 Complex, sp Complex criteria sp none duplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 7544 7544 Viability (synthetic lethal) A375 D-006573-03 Complex, sp Complex criteria sp Increased viability with MLN4924 (a NAE inhibitor) duplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 7544 7544 Viability (synthetic lethal) A375 D-006573-04 Complex, sp Complex criteria sp Synthetic lethal with MLN4924 (a NAE inhibitor) duplicate screen GR00250-A-2 Combinatorial effect with MLN4924, a NAE inhibitor (2) 23100467 7544 7544 Viability (synthetic lethal) A375 D-006573-05 Complex, sp Complex criteria sp none duplicate screen GR00253-A hepcidin regulation 24385536 7544 NM_003411 hepcidin::fluc mRNA expression Huh7 np Z-score >= 1.755 OR <= -1.389 0.94 none GR00255-A-1 Negative genetic interactions (1) 24104479 7544 7544 shRNA abundance HCT116 TRCN0000017328,TRCN0000017329,TRCN0000017330,TRCN0000017331,TRCN0000017332 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.645976908 none GR00255-A-2 Negative genetic interactions (2) 24104479 7544 7544 shRNA abundance HCT116 TRCN0000017328,TRCN0000017329,TRCN0000017330,TRCN0000017331,TRCN0000017332 differential Gene Activity Ranking Profile (dGARP) < -1.0 0.398978887 none GR00255-A-3 Negative genetic interactions (3) 24104479 7544 7544 shRNA abundance HCT116 TRCN0000017328,TRCN0000017329,TRCN0000017330,TRCN0000017331,TRCN0000017332 differential Gene Activity Ranking Profile (dGARP) < -1.2 0.039999068 none GR00255-A-4 Negative genetic interactions (4) 24104479 7544 7544 shRNA abundance HCT116 TRCN0000017328,TRCN0000017329,TRCN0000017330,TRCN0000017331,TRCN0000017332 differential Gene Activity Ranking Profile (dGARP) < -1.2 -0.087556832 none GR00255-A-5 Negative genetic interactions (5) 24104479 7544 7544 shRNA abundance HCT116 TRCN0000017328,TRCN0000017329,TRCN0000017330,TRCN0000017331,TRCN0000017332 differential Gene Activity Ranking Profile (dGARP) < -0.8 0.046886505 none GR00250-A-1 Combinatorial effect with MLN4924, a NAE inhibitor (1) 23100467 7544 7544 Viability (synthetic lethal) A375 M-006573-01 Complex, sp Complex criteria sp Increased viability with MLN4924 (a NAE inhibitor) duplicate screen, sextuplicate screen GR00057-A-1 Wnt/beta-catenin pathway regulation (1) 18621708 7544 NM_003411 Wnt pathway reporter HeLa M-006573-01 Z-score > 4 1.43 none GR00057-A-2 Wnt/beta-catenin pathway regulation (2) 18621708 7544 NM_003411 Wnt pathway reporter HeLa M-006573-01 Complex, SP Complex criteria sp none GR00293-A Combinatorial effect with paclitaxel 24860162 7544 Viability HCC366 np Z-score < -2.5 0.542 none GR00300-A Combinatorial effect with RAF inhibitor PLX4720 23288408 7544 shRNA abundance A375 TRCN0000017332,TRCN0000017331,TRCN0000017330,TRCN0000017329,TRCN0000017328 Number of shRNAs ranked Top1000 > 2 0 none GR00302-A Antiviral innate immunity regulation 23785285 7544 7544 RLR pathway reporter HEK293T TRCN0000017332,TRCN0000017330,TRCN0000017329 Strictly standardized mean difference (SSMD) <= -1.314 OR >= 1.662 1.859 Upregulation of RLR pathway after Sendai virus (SeV) infection GR00303-A Clear cell renal cell carcinoma (ccRCC) survival regulation 22362593 7544 NM_003411 Proliferation and Viability VHL-deficient RCC4 np Z-score <= -3 -0.13 none GR00310-A-1 Sindbis virus (SINV) infection (1) 24367265 7544 7544 Sindbis virus (SINV) reporter U2OS np Z-score < -3 OR > 2 0.36 none GR00312-A NOD2 pathway regulation 23322906 7544 7544 NF-kappaB reporter HEK 293 np Normalized percent inhibition < -20 OR > 60; Inconclusive: < -20 and > 120 % viability OR > 60 and < 70 % viability 46.5 none 68% viability GR00313-A TNF-alpha pathway regulation 22733992 7544 NM_003411 NFkappaB pathway reporter HEK293T np Z-score <= -2.5 plus additional filters 0.9 none GR00318-A Huntingtin toxicity 23209424 7544 7544 Caspase 3/7 activity HEK293T np Sum of normalized caspase 3/7 activity mean and standard error < 0.683 1.282 none siRNA set: druggable genome GR00095-A p53 pathway components 15042092 7544 M30607 Proliferation BJ-TERT-tsLT fibroblasts np np np np none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 7544 7544 shRNA abundance K562 TRCN0000017328 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.7274999999999991 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 7544 7544 shRNA abundance K562 TRCN0000017331 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.14749999999999908 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 7544 7544 shRNA abundance K562 TRCN0000017332 Log2 ratio <= -2 (shRNA abundance <= 25%) -0.6549999999999994 none GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 7544 7544 shRNA abundance K562 TRCN0000017329 Log2 ratio <= -2 (shRNA abundance <= 25%) -2.727500000000001 shRNA abundance <= 25% GR00343-S Lentiviral shRNA "Achilles Heel" screen 26058080 7544 7544 shRNA abundance K562 TRCN0000017330 Log2 ratio <= -2 (shRNA abundance <= 25%) 0.4775000000000009 none GR00123-A Combinatorial effect with nutlin-3 16474381 7544 M30607 Viability MCF-7 110653,110652,110651 log2 ratio np np none GR00351-A-1 Orthopoxvirus infection (1) 24516381 7544 Vaccinia virus (VACV-A4L) infection A549 np Number of replicates in which second best hairpin scored among Top 500 > 0 2 Resistant to vaccinia virus (VACV-A4L) infection GR00369-A Combinatorial effect with FBW7 26354767 7544 7544 shRNA abundance HCT116 [object Object] Gene Activity Ranking Profile (GARP) Difference of FBW7(-/-) and wt GARP scores that fell >3 SD away from the mean -0.01999999999999999 none GR00371-A-1 Nanog expression in absence of bFGF and TGFbeta 26232226 7544 7544 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 1.29121011097 none Ambion GR00371-A-2 Nanog expression in presence of TGFbeta inhibitor 26232226 7544 ZFY NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.175176419458 none Ambion GR00371-A-3 Nanog expression in presence of MEK inhibitor 26232226 7544 7544 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.806651823281 none Ambion GR00371-A-4 Nanog expression in presence of PI3K inhibitor 26232226 7544 7544 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] 0.370385144626 none Ambion GR00371-A-5 Nanog expression in presence of retinoic acid 26232226 7544 7544 NANOG expression NANOG-GFP H1 hESC [object Object] Z-score >1,25 OR >1,5 [in at least two replicates] -0.372202683559 none Ambion GR00376-A-1 Mitigators of SS1P-induced immunotoxicity 25713356 7544 7544 Viability KB cells [object Object] RSA P-value <0.001 0.001207791 none GR00376-A-2 Sensitizers of SS1P-induced immunotoxicity 25713356 7544 7544 Viability KB cells [object Object] RSA P-value <0.001 0.931169428 none GR00378-A Poliovirus vaccine production 26581994 7544 Infection with Attenuated Poliovirus HEp-2C [object Object] Z-score >=3 -1.646068902 none GR00381-A-1 Regulation of mammary epithelial cell growth (1) 25572802 7544 NM_003411 Viability 184-hTERT-L9 (mammary epithelial cells) [object Object] Percent growth < 25 % AND p-value < 0.05 16.733 Decreased viability GR00386-A-1 NOD2 stimulation by MDP 25170077 7544 7544 Viability HEK293 stably expressing NOD2 [object Object] Percentage growth Decreased: <70, increased: >120 60.9967974448916 Decreased viability GR00386-A-2 MDP-induced IL-8 secretion 25170077 7544 7544 IL-8 secretion HEK293 stably expressing NOD2 [object Object] Percent inhibition of IL-8 secretion Increased: <-300, Decreased: >60 -87.4 none GR00400-S-1 Combinatorial effect with vorinostat (1) 25977774 7544 7544 Caspase 3/7 activity HCT116 (Vorinostat resistant subclone) M-006573-01 Z-score >=5.13 0.16 none GR00402-S-1 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (1) 7544 7544 The percentage of infected cells A549 SIR0001724 Z-score > 5 -2.81439452088638 no effect 5 days post-infection GR00402-S-2 Host restriction factor for the Mycobacterium tuberculosis infection to A549 cells (2) 7544 7544 The percentage of infected cells A549 SIR0001724 Z-score > -3 -4.7956095754437715 Decreased viability 5 days post-infection